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MedKoo Cat#: 464907 | Name: CGP-53437

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP-53437 is a novel HIV-1 protease inhibitor, also potently inhibiting major aspartyl peptidase 1 (May1), a secreted Cryptococcus neoformans protease.

Chemical Structure

CGP-53437
CGP-53437
CAS#150736-68-8

Theoretical Analysis

MedKoo Cat#: 464907

Name: CGP-53437

CAS#: 150736-68-8

Chemical Formula: C42H56N4O7

Exact Mass: 728.4149

Molecular Weight: 728.93

Elemental Analysis: C, 69.21; H, 7.74; N, 7.69; O, 15.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
CGP-53437; CGP53437; CGP 53437;
IUPAC/Chemical Name
tert-butyl ((2S,3S,5R)-5-benzyl-3-hydroxy-6-(((S)-3-methyl-1-(((S)-1-morpholino-1-oxo-3-phenylpropan-2-yl)amino)-1-oxobutan-2-yl)amino)-6-oxo-1-phenylhexan-2-yl)carbamate
InChi Key
NAJDZKGRZBLNON-RKGCBODKSA-N
InChi Code
InChI=1S/C42H56N4O7/c1-29(2)37(39(49)43-35(27-32-19-13-8-14-20-32)40(50)46-21-23-52-24-22-46)45-38(48)33(25-30-15-9-6-10-16-30)28-36(47)34(26-31-17-11-7-12-18-31)44-41(51)53-42(3,4)5/h6-20,29,33-37,47H,21-28H2,1-5H3,(H,43,49)(H,44,51)(H,45,48)/t33-,34+,35+,36+,37+/m1/s1
SMILES Code
O[C@@H](C[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N2CCOCC2)=O)=O)=O)CC3=CC=CC=C3)[C@@H](NC(OC(C)(C)C)=O)CC4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 728.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Flesch G, Mann C, Degen PH. Quantitative determination of CGP 61755, a protease inhibitor, in plasma and urine by high-performance liquid chromatography and fluorescence detection. J Chromatogr B Biomed Sci Appl. 1997 Aug 15;696(1):123-30. doi: 10.1016/s0378-4347(97)00210-7. PMID: 9300916. 2: Flesch G, Mann C, Boss E, Lang M, Degen PH, Dieterle W. Quantitative determination of CGP 53,437, a new HIV protease inhibitor, in plasma by high- performance liquid chromatography and fluorescence detection. J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):155-61. doi: 10.1016/0378-4347(94)80082-0. PMID: 7952063. 3: Alteri E, Bold G, Cozens R, Faessler A, Klimkait T, Lang M, Lazdins J, Poncioni B, Roesel JL, Schneider P, et al. CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity. Antimicrob Agents Chemother. 1993 Oct;37(10):2087-92. doi: 10.1128/AAC.37.10.2087. PMID: 8257128; PMCID: PMC192233.