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MedKoo Cat#: 464902 | Name: RF3286

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RF3286 is a novel Highly Selective Neuropeptide FF1 Receptor Antagonist, Potently Preventing Opioid-Induced Hyperalgesia.

Chemical Structure

RF3286
RF3286
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464902

Name: RF3286

CAS#: unknown

Chemical Formula: C27H36N6O3

Exact Mass: 492.2849

Molecular Weight: 492.62

Elemental Analysis: C, 65.83; H, 7.37; N, 17.06; O, 9.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RF3286; RF 3286; RF-3286;
IUPAC/Chemical Name
(S)-N-((R)-1-amino-4-methyl-1-oxopentan-2-yl)-2-(3,3-diphenylacrylamido)-5-guanidinopentanamide
InChi Key
DHCKIFBNEHPVAG-XZOQPEGZSA-N
InChi Code
InChI=1S/C27H36N6O3/c1-18(2)16-23(25(28)35)33-26(36)22(14-9-15-31-27(29)30)32-24(34)17-21(19-10-5-3-6-11-19)20-12-7-4-8-13-20/h3-8,10-13,17-18,22-23H,9,14-16H2,1-2H3,(H2,28,35)(H,32,34)(H,33,36)(H4,29,30,31)/t22-,23+/m0/s1
SMILES Code
NC([C@@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC(/C=C(C1=CC=CC=C1)/C2=CC=CC=C2)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 492.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Quillet R, Schneider S, Utard V, Drieu la Rochelle A, Elhabazi K, Henningsen JB, Gizzi P, Schmitt M, Kugler V, Simonneaux V, Ilien B, Simonin F, Bihel F. Identification of an N-acylated-DArg-Leu-NH2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia. J Med Chem. 2021 Jun 10;64(11):7555-7564. doi: 10.1021/acs.jmedchem.1c00256. Epub 2021 May 19. PMID: 34008968.