DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.
MedKoo Cat#: 464894
Name: DSRM-3716
CAS#: 58142-99-7
Chemical Formula: C9H6IN
Exact Mass: 254.9545
Molecular Weight: 255.06
Elemental Analysis: C, 42.38; H, 2.37; I, 49.76; N, 5.49
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| Ethanol | 25.5 | 100.00 | |
| DMSO | 25.5 | 100.00 |
The following data is based on the product molecular weight 255.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
