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MedKoo Cat#: 577008 | Name: MDL-27048

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDL-27048 is a powerful and reversible microtubule inhibitor.

Chemical Structure

MDL-27048
MDL-27048
CAS#124711-23-5

Theoretical Analysis

MedKoo Cat#: 577008

Name: MDL-27048

CAS#: 124711-23-5

Chemical Formula: C20H23NO3

Exact Mass: 325.1678

Molecular Weight: 325.41

Elemental Analysis: C, 73.82; H, 7.12; N, 4.30; O, 14.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MDL27048; MDL 27048; MDL-27048
IUPAC/Chemical Name
2-Propen-1-one, 1-(2,5-dimethoxyphenyl)-3-(4-(dimethylamino)phenyl)-2-methyl-, (E)-
InChi Key
AJMWJDGKNKNYEW-WYMLVPIESA-N
InChi Code
InChI=1S/C20H23NO3/c1-14(12-15-6-8-16(9-7-15)21(2)3)20(22)18-13-17(23-4)10-11-19(18)24-5/h6-13H,1-5H3/b14-12+
SMILES Code
COc1ccc(OC)c(c1)C(=O)\C(=C\c2ccc(cc2)N(C)C)\C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 325.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Peyrot V, Leynadier D, Sarrazin M, Briand C, Menendez M, Laynez J, Andreu JM. Mechanism of binding of the new antimitotic drug MDL 27048 to the colchicine site of tubulin: equilibrium studies. Biochemistry. 1992 Nov 17;31(45):11125-32. doi: 10.1021/bi00160a024. PMID: 1445852. 2. Peyrot V, Leynadier D, Sarrazin M, Briand C, Rodriquez A, Nieto JM, Andreu JM. Interaction of tubulin and cellular microtubules with the new antitumor drug MDL 27048. A powerful and reversible microtubule inhibitor. J Biol Chem. 1989 Dec 15;264(35):21296-301. PMID: 2592375.

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