Nitidine | CAS# 6872-57-7 | anti-malarial activity

MedKoo Cat#: 414410 | Name: Nitidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nitidine is a benzophenanthridine alkaloid found in species of the genus Zanthoxylum , notably in Zanthoxylum nitidum. This compound has an anti-malarial activity.

Chemical Structure

Nitidine

CAS#6872-57-7

Theoretical Analysis

MedKoo Cat#: 414410

Name: Nitidine

CAS#: 6872-57-7

Chemical Formula: C21H18NO4+

Exact Mass: 348.1230

Molecular Weight: 348.38

Elemental Analysis: C, 72.40; H, 5.21; N, 4.02; O, 18.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Nitidine; NSC146397; NSC-146397; NSC 146397

IUPAC/Chemical Name

(1,3)Benzodioxolo(5,6-c)phenanthridinium, 2,3-dimethoxy-12-methyl-

InChi Key

KKMPSGJPCCJYRV-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H18NO4/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22/h4-10H,11H2,1-3H3/q+1

SMILES Code

C[N+]1=CC2=CC(OC)=C(OC)C=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 348.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xiong DD, Feng ZB, Lai ZF, Qin Y, Liu LM, Fu HX, He RQ, Wu HY, Dang YW, Chen G, Luo DZ. High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma. Cell Death Dis. 2019 Sep 10;10(9):658. doi: 10.1038/s41419-019-1890-9. PMID: 31506425; PMCID: PMC6737102. 2: Khan H, Hadda TB, Touzani R. Diverse Therapeutic Potential of Nitidine, A Comprehensive Review. Curr Drug Metab. 2018;19(12):986-991. doi: 10.2174/1389200219666180628165643. PMID: 29956622. 3: Cui Y, Wu L, Cao R, Xu H, Xia J, Wang ZP, Ma J. Antitumor functions and mechanisms of nitidine chloride in human cancers. J Cancer. 2020 Jan 1;11(5):1250-1256. doi: 10.7150/jca.37890. PMID: 31956371; PMCID: PMC6959075. 4: Yang XG, Jiang BW, Jing QQ, Li WJ, Tan LP, Bao YL, Song ZB, Yu CL, Liu L, Liu YC, Li YX. Nitidine chloride induces S phase cell cycle arrest and mitochondria- dependent apoptosis in HaCaT cells and ameliorates skin lesions in psoriasis- like mouse models. Eur J Pharmacol. 2019 Nov 15;863:172680. doi: 10.1016/j.ejphar.2019.172680. Epub 2019 Sep 26. PMID: 31563649. 5: Xu H, Cao T, Zhang X, Shi Y, Zhang Q, Chai S, Yu L, Jin G, Ma J, Wang P, Li Y. Nitidine Chloride Inhibits SIN1 Expression in Osteosarcoma Cells. Mol Ther Oncolytics. 2019 Feb 5;12:224-234. doi: 10.1016/j.omto.2019.01.005. PMID: 30847386; PMCID: PMC6389778. 6: Mao X, Hu Z, Wang Q, Zhang N, Zhou S, Peng Y, Zheng J. Nitidine Chloride Is a Mechanism-Based Inactivator of CYP2D6. Drug Metab Dispos. 2018 Aug;46(8):1137-1145. doi: 10.1124/dmd.117.079780. Epub 2018 May 17. PMID: 29773554. 7: Gao L, Xiong DD, He RQ, Lai ZF, Liu LM, Huang ZG, Yang X, Wu HY, Yang LH, Ma J, Li SH, Lin P, Yang H, Luo DZ, Chen G, Dang YW. Identifying TF-miRNA-mRNA regulatory modules in nitidine chloride treated HCC xenograft of nude mice. Am J Transl Res. 2019 Dec 15;11(12):7503-7522. PMID: 31934297; PMCID: PMC6943467. 8: Avila-Carrasco L, Majano P, Sánchez-Toméro JA, Selgas R, López-Cabrera M, Aguilera A, González Mateo G. Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition. Front Pharmacol. 2019 Jul 30;10:715. doi: 10.3389/fphar.2019.00715. PMID: 31417401; PMCID: PMC6682706. 9: Zhang J, Cao R, Lian C, Cao T, Shi Y, Ma J, Wang P, Xia J. Nitidine chloride suppresses NEDD4 expression in lung cancer cells. Aging (Albany NY). 2020 Dec 3;13(1):782-793. doi: 10.18632/aging.202185. Epub 2020 Dec 3. PMID: 33288736; PMCID: PMC7834991. 10: Mao X, Wang J, Wang Q, Yang L, Li Y, Lin H, Peng Y, Zheng J. Nitidine Chloride-Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism. Drug Metab Dispos. 2019 Aug;47(8):919-927. doi: 10.1124/dmd.119.086892. Epub 2019 May 30. PMID: 31147316.