Synonym
MDL 103323; MDL103323; MDL-103323
IUPAC/Chemical Name
(E)-4-(4-(2-chloro-1,2-diphenylvinyl)phenoxy)-N,N-diethylbutan-1-amine
InChi Key
UTYMHSHRSOOSEY-BYYHNAKLSA-N
InChi Code
InChI=1S/C28H32ClNO/c1-3-30(4-2)21-11-12-22-31-26-19-17-24(18-20-26)27(23-13-7-5-8-14-23)28(29)25-15-9-6-10-16-25/h5-10,13-20H,3-4,11-12,21-22H2,1-2H3/b28-27+
SMILES Code
CCN(CC)CCCCOc1ccc(cc1)\C(=C(\Cl)/c2ccccc2)\c3ccccc3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
434.02
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Chavassieux P, Garnero P, Duboeuf F, Vergnaud P, Brunner-Ferber F, Delmas PD, Meunier PJ. Effects of a new selective estrogen receptor modulator (MDL 103,323) on cancellous and cortical bone in ovariectomized ewes: a biochemical, histomorphometric, and densitometric study. J Bone Miner Res. 2001 Jan;16(1):89-96. doi: 10.1359/jbmr.2001.16.1.89. PMID: 11149494.
2. Ammann P, Bourrin S, Bonjour JP, Brunner F, Meyer JM, Rizzoli R. The new selective estrogen receptor modulator MDL 103,323 increases bone mineral density and bone strength in adult ovariectomized rats. Osteoporos Int. 1999;10(5):369-76. doi: 10.1007/s001980050242. PMID: 10591834.
3. Bourrin S, Ammann P, Bonjour JP, Rizzoli R. Recovery of proximal tibia bone mineral density and strength, but not cancellous bone architecture, after long-term bisphosphonate or selective estrogen receptor modulator therapy in aged rats. Bone. 2002 Jan;30(1):195-200. doi: 10.1016/s8756-3282(01)00661-5. PMID: 11792585.
4. Baumann RJ, Bush TL, Cross-Doersen DE, Cashman EA, Wright PS, Zwolshen JH, Davis GF, Matthews DP, Bender DM, Bitonti AJ. Clomiphene analogs with activity in vitro and in vivo against human breast cancer cells. Biochem Pharmacol. 1998 Mar 15;55(6):841-51. doi: 10.1016/s0006-2952(97)00574-1. PMID: 9586957.
