MDL-100173 | CAS# 142695-09-8 | Biochemical

MedKoo Cat#: 576987 | Name: MDL-100173

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDL-100173 is a dual angiotensin-converting enzyme (ACE)/neutral endopeptidase (NEP) inhibitor.

Chemical Structure

MDL-100173

CAS#142695-09-8

Theoretical Analysis

MedKoo Cat#: 576987

Name: MDL-100173

CAS#: 142695-09-8

Chemical Formula: C24H26N2O4S

Exact Mass: 438.1613

Molecular Weight: 438.54

Elemental Analysis: C, 65.73; H, 5.98; N, 6.39; O, 14.59; S, 7.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

MDL100173; MDL 100173; MDL-100173

IUPAC/Chemical Name

Pyrido(2,1-a)(2)benzazepine-4-carboxylic acid, 1,2,3,4,6,7,8,12b-octahydro-7-((2-mercapto-1-oxo-3-phenylpropyl)amino)-6-oxo-, (4S-(4alpha,7alpha(R*),12bbeta))-

InChi Key

RIWRWPXUDHZKIO-WOZUAGRISA-N

InChi Code

InChI=1S/C24H26N2O4S/c27-22(21(31)13-15-7-2-1-3-8-15)25-18-14-16-9-4-5-10-17(16)19-11-6-12-20(24(29)30)26(19)23(18)28/h1-5,7-10,18-21,31H,6,11-14H2,(H,25,27)(H,29,30)/t18-,19+,20-,21-/m0/s1

SMILES Code

OC(=O)[C@@H]1CCC[C@H]2N1C(=O)[C@H](Cc3ccccc23)NC(=O)[C@@H](S)Cc4ccccc4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 438.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Emmons GT, Argenti R, Martin LL, Martin NE, Jensen BK. Pharmacokinetics of M100240 and MDL 100,173, a dual angiotensin-converting enzyme/neutral endopeptidase inhibitor, in healthy young and elderly volunteers. J Clin Pharmacol. 2004 Aug;44(8):901-5. doi: 10.1177/0091270004267588. PMID: 15286094. 2. French JF, Flynn GA, Giroux EL, Mehdi S, Anderson B, Beach DC, Koehl JR, Dage RC. Characterization of a dual inhibitor of angiotensin I-converting enzyme and neutral endopeptidase. J Pharmacol Exp Ther. 1994 Jan;268(1):180-6. PMID: 8301555. 3.Hwang KK, Jiang L, Ren Y, Martin LL, Martin NE. Site-specific absorption of M100240 and MDL 100,173 in rats evaluated using Sweetana-Grass diffusion chamber technology. J Pharmacol Toxicol Methods. 2002 Sep-Oct;48(2):97-101. doi: 10.1016/S1056-8719(03)00036-4. PMID: 14565566.