Synonym
Isobergapten; 5-methoxy Angelicin; 5 methoxy Angelicin;
IUPAC/Chemical Name
5-methoxy-2H-furo[2,3-h]chromen-2-one
InChi Key
AJSPSRWWZBBIOR-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H8O4/c1-14-9-6-10-8(4-5-15-10)12-7(9)2-3-11(13)16-12/h2-6H,1H3
SMILES Code
O=C1OC2=C(C(OC)=CC3=C2C=CO3)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
216.19
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kviesis J, Kļimenkovs I, Arbidans L, Podjava A, Kļaviņš M, Liepiņš E. Evaluation of furanocoumarins from seeds of the wild parsnip (Pastinaca sativa L. s.l.). J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jan 15;1105:54-66. doi: 10.1016/j.jchromb.2018.12.012. Epub 2018 Dec 12. PMID: 30562630.
2: Zhang HL, Wu XY, Mi J, Peng YJ, Wang ZG, Liu Y, Wu XL, Gao Y. A New Anti- Inflammatory Alkaloid from Roots of Heracleum dissectum. Chem Biodivers. 2017 Sep;14(9). doi: 10.1002/cbdv.201700184. Epub 2017 Aug 20. PMID: 28556437.
3: Zeng XY, Dong S, He NN, Jiang CJ, Dai Y, Xia YF. Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration. Fitoterapia. 2015 Sep;105:119-26. doi: 10.1016/j.fitote.2015.06.014. Epub 2015 Jun 20. PMID: 26102179.
4: Sumiyoshi M, Sakanaka M, Taniguchi M, Baba K, Kimura Y. Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation. J Nat Med. 2014 Jan;68(1):83-94. doi: 10.1007/s11418-013-0774-z. Epub 2013 May 7. PMID: 23649674.
5: O'Neill T, Johnson JA, Webster D, Gray CA. The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. J Ethnopharmacol. 2013 May 2;147(1):232-7. doi: 10.1016/j.jep.2013.03.009. Epub 2013 Mar 13. PMID: 23501157.
6: Zhao B, Yang X, Yang X, Zhang L. [Chemical constituents of roots of Saposhnikovia divaricata]. Zhongguo Zhong Yao Za Zhi. 2010 Jun;35(12):1569-72. Chinese. doi: 10.4268/cjcmm20101214. PMID: 20815209.
7: Fu Y, Bai Y, Dawa Z, Bai B, Ding L. [Chemical constituents of Incarvillea younghusbandii]. Zhongguo Zhong Yao Za Zhi. 2010 Jan;35(1):58-62. Chinese. doi: 10.4268/cjcmm20100112. PMID: 20349717.
8: Orhan I, Tosun F, Sener B. Coumarin, anthroquinone and stilbene derivatives with anticholinesterase activity. Z Naturforsch C J Biosci. 2008 May- Jun;63(5-6):366-70. doi: 10.1515/znc-2008-5-610. PMID: 18669022.
9: Kavli G, Raa J, Johnson BE, Volden G, Haugsbø S. Furocoumarins of Heracleum laciniatum: isolation, phototoxicity, absorption and action spectra studies. Contact Dermatitis. 1983 Jul;9(4):257-62. doi: 10.1111/j.1600-0536.1983.tb04386.x. PMID: 6617185.
10: Kavli G, Volden G, Raa J. Accidental induction of photocontact allergy to Heracleum laciniatum. Acta Derm Venereol. 1982;62(5):435-8. PMID: 6183897.
