MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 414399 | Name: Niravoline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Niravoline is a kappa-opioid agonist.

Chemical Structure

Niravoline
Niravoline
CAS#130610-93-4

Theoretical Analysis

MedKoo Cat#: 414399

Name: Niravoline

CAS#: 130610-93-4

Chemical Formula: C22H25N3O3

Exact Mass: 379.1896

Molecular Weight: 379.46

Elemental Analysis: C, 69.64; H, 6.64; N, 11.07; O, 12.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Niravoline
IUPAC/Chemical Name
N-Methyl-2-(m-nitrophenyl)-N-((1S,2S)-2-(1-pyrrolidinyl)-1-indanyl)acetamide
InChi Key
ZSDAQBWGAOKTSI-UNMCSNQZSA-N
InChi Code
InChI=1S/C22H25N3O3/c1-23(21(26)14-16-7-6-9-18(13-16)25(27)28)22-19-10-3-2-8-17(19)15-20(22)24-11-4-5-12-24/h2-3,6-10,13,20,22H,4-5,11-12,14-15H2,1H3/t20-,22-/m0/s1
SMILES Code
O=C(N(C)[C@@H]1[C@@H](N2CCCC2)CC3=C1C=CC=C3)CC4=CC=CC([N+]([O-])=O)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 379.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nagao S, Bemana I, Kuratani H, Takahashi E, Nakamura T. Niravoline, a selective kappa-opioid receptor agonist effectively reduces elevated intracranial pressure. Exp Brain Res. 2000 Feb;130(3):338-44. doi: 10.1007/s002219900251. PMID: 10706433. 2: Bosch-Marcé M, Poo JL, Jiménez W, Bordas N, Leivas A, Morales-Ruiz M, Muñoz RM, Pérez M, Arroyo V, Rivera F, Rodés J. Comparison of two aquaretic drugs (niravoline and OPC-31260) in cirrhotic rats with ascites and water retention. J Pharmacol Exp Ther. 1999 Apr;289(1):194-201. PMID: 10087004. 3: Takahashi H, Hamada H, Teramoto A. Usefulness of niravoline, an arginine vasopressin inhibitor, on tumour-origin brain oedema. Acta Neurochir Suppl. 2000;76:323-7. doi: 10.1007/978-3-7091-6346-7_66. PMID: 11450035. 4: Bellissant E, Denolle T, Sinnassamy P, Bichet DG, Giudicelli JF, Lecoz F, Gandon JM, Allain H. Systemic and regional hemodynamic and biological effects of a new kappa-opioid agonist, niravoline, in healthy volunteers. J Pharmacol Exp Ther. 1996 Jul;278(1):232-42. PMID: 8764356. 5: Gadano A, Moreau R, Pessione F, Trombino C, Giuily N, Sinnassamy P, Valla D, Lebrec D. Aquaretic effects of niravoline, a kappa-opioid agonist, in patients with cirrhosis. J Hepatol. 2000 Jan;32(1):38-42. doi: 10.1016/s0168-8278(00)80187-7. PMID: 10673065. 6: Moreau R, Cailmail S, Hamon G, Lebrec D. Renal and haemodynamic responses to a novel kappa opioid receptor agonist, niravoline (RU 51,599), in rats with cirrhosis. J Gastroenterol Hepatol. 1996 Sep;11(9):857-63. doi: 10.1111/j.1440-1746.1996.tb00093.x. PMID: 8889966. 7: Guéniau C, Oberlander C. The kappa opioid agonist niravoline decreases brain edema in the mouse middle cerebral artery occlusion model of stroke. J Pharmacol Exp Ther. 1997 Jul;282(1):1-6. PMID: 9223533. 8: Bemana I, Nagao S. Effects of niravoline (RU 51599), a selective kappa-opioid receptor agonist on intracranial pressure in gradually expanding extradural mass lesion. J Neurotrauma. 1998 Feb;15(2):117-24. doi: 10.1089/neu.1998.15.117. PMID: 9512087. 9: Jiménez W. Agentes acuaréticos [Aquaretic agents]. Nefrologia. 2002;22 Suppl 5:52-5. Spanish. PMID: 12107918. 10: Brooks DP, Valente M, Petrone G, Depalma PD, Sbacchi M, Clarke GD. Comparison of the water diuretic activity of kappa receptor agonists and a vasopressin receptor antagonist in dogs. J Pharmacol Exp Ther. 1997 Mar;280(3):1176-83. PMID: 9067301.

View History

Nirtetralin

Nirtetralin