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MedKoo Cat#: 414390 | Name: Abierixin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Abierixin is a new polyether antibiotic

Chemical Structure

Abierixin
Abierixin
CAS#100634-16-0

Theoretical Analysis

MedKoo Cat#: 414390

Name: Abierixin

CAS#: 100634-16-0

Chemical Formula: C40H68O11

Exact Mass: 724.4762

Molecular Weight: 724.97

Elemental Analysis: C, 66.27; H, 9.45; O, 24.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Abierixin
IUPAC/Chemical Name
(E)-7-hydroxy-8-(2-(5'-(6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-2,4-dimethyloct-2-enoic acid
InChi Key
JQESXHYTUWEFCM-MFKUBSTISA-N
InChi Code
InChI=1S/C40H68O11/c1-22(15-25(4)36(43)44)11-12-29(42)18-30-19-31(46-10)28(7)40(48-30)27(6)20-38(9,51-40)33-13-14-37(8,49-33)35-24(3)17-32(47-35)34-23(2)16-26(5)39(45,21-41)50-34/h15,22-24,26-35,41-42,45H,11-14,16-21H2,1-10H3,(H,43,44)/b25-15+
SMILES Code
COC1CC(OC2(C1C)OC(CC2C)(C3CCC(O3)(C4OC(C5OC(CO)(C(CC5C)C)O)CC4C)C)C)CC(CCC(/C=C(C(O)=O)\C)C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 724.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: David L, Leal Ayala H, Tabet JC. Abierixin, a new polyether antibiotic. Production, structural determination and biological activities. J Antibiot (Tokyo). 1985 Dec;38(12):1655-63. doi: 10.7164/antibiotics.38.1655. PMID: 3841534. 2: Supong K, Sripreechasak P, Tanasupawat S, Danwisetkanjana K, Rachtawee P, Pittayakhajonwut P. Investigation on antimicrobial agents of the terrestrial Streptomyces sp. BCC71188. Appl Microbiol Biotechnol. 2017 Jan;101(2):533-543. doi: 10.1007/s00253-016-7804-1. Epub 2016 Aug 23. PMID: 27554496. 3: Leulmi N, Sighel D, Defant A, Khenaka K, Boulahrouf A, Mancini I. Nigericin and grisorixin methyl ester from the Algerian soil-living Streptomyces youssoufiensis SF10 strain: a computational study on their epimeric structures and evaluation of glioblastoma stem cells growth inhibition. Nat Prod Res. 2019 Jan;33(2):266-273. doi: 10.1080/14786419.2018.1446014. Epub 2018 Mar 7. PMID: 29513090. 4: Hillaire MC, Gomez L, Jouany JP. In vitro study of the response of rumen microorganisms to different doses of abierixin, a new antibiotic ionophore, according to the nature of nitrogen supplies. Arch Tierernahr. 1990 Jan- Feb;40(1-2):65-74. doi: 10.1080/17450399009428384. PMID: 2344276. 5: Gomez L, Hillaire MC, Jouany JP. In vitro study (Rusitec) of the action of abierixin, a new ionophore antibiotic, on the end products of fermentation and the degradation of nitrogen in the rumen. Arch Tierernahr. 1990 Mar;40(3):229-38. doi: 10.1080/17450399009428398. PMID: 2383178. 6: Mouslim J, Cuer A, David L, Tabet JC. Biosynthetic study on the polyether carboxylic antibiotic, nigericin production and biohydroxylation of grisorixin by nigericin-producing Streptomyces hygroscopicus NRRL B-1865. J Antibiot (Tokyo). 1995 Sep;48(9):1011-4. doi: 10.7164/antibiotics.48.1011. PMID: 7592045. 7: Niu S, Li S, Tian X, Hu T, Ju J, Ynag X, Zhang S, Zhang C. [Isolation and structural elucidation of secondary metabolites from marine Streptomyces sp. SCSIO 1934]. Zhongguo Zhong Yao Za Zhi. 2011 Jul;36(13):1763-8. Chinese. PMID: 22032140. 8: Supong K, Thawai C, Choowong W, Kittiwongwattana C, Thanaboripat D, Laosinwattana C, Koohakan P, Parinthawong N, Pittayakhajonwut P. Antimicrobial compounds from endophytic Streptomyces sp. BCC72023 isolated from rice (Oryza sativa L.). Res Microbiol. 2016 May;167(4):290-298. doi: 10.1016/j.resmic.2016.01.004. Epub 2016 Jan 22. PMID: 26809052. 9: Kim YH, Yoo JS, Lee CH, Goo YM, Kim MS. Application of fast atom bombardment combined with tandem mass spectrometry to the structural elucidation of O-demethylabierixin and related polyether antibiotics. J Mass Spectrom. 1996 Aug;31(8):855-60. doi: 10.1002/(SICI)1096-9888(199608)31:8<855::AID- JMS363>3.0.CO;2-U. PMID: 8799311. 10: Harvey BM, Mironenko T, Sun Y, Hong H, Deng Z, Leadlay PF, Weissman KJ, Haydock SF. Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137. Chem Biol. 2007 Jun;14(6):703-14. doi: 10.1016/j.chembiol.2007.05.011. PMID: 17584617.

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