Hydroxyterfenadine | CAS# 76815-56-0 | Biochemical

MedKoo Cat#: 576980 | Name: Hydroxyterfenadine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydroxyterfenadine is the hydroxylated metabolite of Terfenadine.

Chemical Structure

Hydroxyterfenadine

CAS#76815-56-0

Theoretical Analysis

MedKoo Cat#: 576980

Name: Hydroxyterfenadine

CAS#: 76815-56-0

Chemical Formula: C32H41NO3

Exact Mass: 487.3086

Molecular Weight: 487.68

Elemental Analysis: C, 78.81; H, 8.47; N, 2.87; O, 9.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Hydroxyterfenadine; MDL 17523; MDL17523; MDL-17523

IUPAC/Chemical Name

alpha-(4-(2-Hydroxy-1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol

InChi Key

ZIQKFOOBIMENJF-UHFFFAOYSA-N

InChi Code

1S/C32H41NO3/c1-31(2,24-34)26-17-15-25(16-18-26)30(35)14-9-21-33-22-19-29(20-23-33)32(36,27-10-5-3-6-11-27)28-12-7-4-8-13-28/h3-8,10-13,15-18,29-30,34-36H,9,14,19-24H2,1-2H3

SMILES Code

CC(C)(CO)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 487.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Jones BC, Hyland R, Ackland M, Tyman CA, Smith DA. Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6. Drug Metab Dispos. 1998 Sep;26(9):875-82. PMID: 9733666. 2. Raeissi SD, Hidalgo IJ, Segura-Aguilar J, Artursson P. Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers. Pharm Res. 1999 May;16(5):625-32. doi: 10.1023/a:1018851919674. PMID: 10350002. 3. von Moltke LL, Greenblatt DJ, Duan SX, Harmatz JS, Wright CE, Shader RI. Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo. J Clin Psychopharmacol. 1996 Apr;16(2):104-12. doi: 10.1097/00004714-199604000-00002. PMID: 8690825. 4. Raeissi SD, Guo Z, Dobson GL, Artursson P, Hidalgo IJ. Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine. Pharm Res. 1997 Aug;14(8):1019-25. doi: 10.1023/a:1012197110917. PMID: 9279883.