NG 011 | CAS# 141731-75-1 | potentiator of nerve growth factor

MedKoo Cat#: 414361 | Name: NG 011

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NG 011 is a potentiator of nerve growth factor; NG 011 and NG 012 are epimers at C24; BK223-A & B are regioisomers.

Chemical Structure

NG 011

CAS#141731-75-1

Theoretical Analysis

MedKoo Cat#: 414361

Name: NG 011

CAS#: 141731-75-1

Chemical Formula: C32H38O15

Exact Mass: 662.2211

Molecular Weight: 662.64

Elemental Analysis: C, 58.00; H, 5.78; O, 36.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

NG 011; NG011; NG-011

IUPAC/Chemical Name

(7R,12S,16R,24R,28R)-2,4,12,19,21-pentahydroxy-7,16,24,28-tetramethyl-7,8,12,13,16,17,24,25,28,29-decahydro-5H,9H,22H,26H-dibenzo[m,w][1,5,10,16,20]pentaoxacyclopentacosine-5,9,14,22,26(11H)-pentaone

InChi Key

UQFKAQNXJTZJAU-RZOYPLJHSA-N

InChi Code

InChI=1S/C32H38O15/c1-15-5-19-9-21(33)11-24(36)29(19)31(41)46-17(3)7-26(38)43-14-23(35)13-28(40)45-16(2)6-20-10-22(34)12-25(37)30(20)32(42)47-18(4)8-27(39)44-15/h9-12,15-18,23,33-37H,5-8,13-14H2,1-4H3/t15-,16-,17-,18-,23+/m1/s1

SMILES Code

C[C@@H]1CC(OC[C@H](CC(O[C@@H](Cc2c(C(O[C@@H](CC(O[C@@H](Cc3c(C(O1)=O)c(O)cc(O)c3)C)=O)C)=O)c(O)cc(O)c2)C)=O)O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 662.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ito M, Maruhashi M, Sakai N, Mizoue K, Hanada K. NG-011 and NG-012, novel potentiators of nerve growth factor. I. Taxonomy, isolation, and physico- chemical and biological properties. J Antibiot (Tokyo). 1992 Oct;45(10):1559-65. doi: 10.7164/antibiotics.45.1559. PMID: 1473982. 2: Ito M, Tsuchida Y, Mizoue K, Hanada K. NG-011 and NG-012, novel potentiators of nerve growth factor. II. The structure determination of NG-011 and NG-012. J Antibiot (Tokyo). 1992 Oct;45(10):1566-72. doi: 10.7164/antibiotics.45.1566. PMID: 1473983. 3: Honeycutt JB, Thayer WO, Baker CE, Ribeiro RM, Lada SM, Cao Y, Cleary RA, Hudgens MG, Richman DD, Garcia JV. HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy. Nat Med. 2017 May;23(5):638-643. doi: 10.1038/nm.4319. Epub 2017 Apr 17. PMID: 28414330; PMCID: PMC5419854. 4: Breinholt J, Jensen GW, Nielsen RI, Olsen CE, Frisvad JC. Antifungal macrocyclic polylactones from Penicillium verruculosum. J Antibiot (Tokyo). 1993 Jul;46(7):1101-8. doi: 10.7164/antibiotics.46.1101. PMID: 8360106.