Benzoylhypaconine is a monoester diterpene alkaloid and hydrolyzed product of hypaconitine that has been found in Aconitum and has anti-inflammatory activity. It inhibits COX-2 activity in a cell-free assay (IC50 = 20.5 µM). Benzoylhypaconine (200 mg/kg) reduces histamine-induced vascular permeability in rats.
MedKoo Cat#: 464797
Name: Benzoylhypaconine
CAS#: 63238-66-4
Chemical Formula: C31H43NO9
Exact Mass: 573.2938
Molecular Weight: 573.68
Elemental Analysis: C, 64.90; H, 7.56; N, 2.44; O, 25.10
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 30.0 | 52.29 | ||
| DMSO | 30.0 | 52.29 | ||
| Ethanol | 30.0 | 52.29 |
The following data is based on the product molecular weight 573.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
