SUN81928, a dimer of MSA-2 via a 3-carbon bridge, is a STING agonist with antitumor activity with (IC50 = 8 nM (HAQ)and 23 nM (WT). SUN81928 exhibited 1:1 binding with hSTING-WT and a slow on-rate (ka = 1.1 × 104 M−1 s−1). SUN81928 was first reported in Science (2020), 369(6506), eaba6098 (Compound 3). This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 555004
Name: SUN81928
CAS#: 2377881-92-8
Chemical Formula: C29H28O8S2
Exact Mass: 568.1226
Molecular Weight: 568.66
Elemental Analysis: C, 61.25; H, 4.96; O, 22.51; S, 11.28
The following data is based on the product molecular weight 568.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
