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MedKoo Cat#: 414299 | Name: Tebufelone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tebufelone is a novel nonsteroidal anti-inflammatory drug (NSAID), of the di-tert-butylphenol (DTBP) class, which displays potent anti-inflammatory, analgesic and anti-pyretic properties in a variety of animal models.

Chemical Structure

Tebufelone
Tebufelone
CAS#112018-00-5

Theoretical Analysis

MedKoo Cat#: 414299

Name: Tebufelone

CAS#: 112018-00-5

Chemical Formula: C20H28O2

Exact Mass: 300.2089

Molecular Weight: 300.44

Elemental Analysis: C, 79.96; H, 9.39; O, 10.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tebufelone; NE11740; NE-11740; NE 11740
IUPAC/Chemical Name
5-Hexyn-1-one, 1-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-
InChi Key
ZHXUEUKVDMWSKV-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H28O2/c1-8-9-10-11-17(21)14-12-15(19(2,3)4)18(22)16(13-14)20(5,6)7/h1,12-13,22H,9-11H2,2-7H3
SMILES Code
C#CCCCC(C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 300.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Powell JH, Meredith MP, Vargas R, McMahon FG, Jain AK. Antipyretic activity of tebufelone (NE-11740) in man. Agents Actions Suppl. 1991;32:45-9. doi: 10.1007/978-3-0348-7405-2_5. PMID: 2069096. 2: Sietsema WK, Kelm GR, Deibel RM, Doyle MJ, Loomans ME, Smyth RE, Kinnett GO, Eichhold TH, Farmer RW. Absorption, bioavailability, and pharmacokinetics of tebufelone in the rat. J Pharm Sci. 1993 Jun;82(6):610-2. doi: 10.1002/jps.2600820613. PMID: 8331535. 3: Sirko SP, Schindler R, Doyle MJ, Weisman SM, Dinarello CA. Transcription, translation and secretion of interleukin 1 and tumor necrosis factor: effects of tebufelone, a dual cyclooxygenase/5-lipoxygenase inhibitor. Eur J Immunol. 1991 Feb;21(2):243-50. doi: 10.1002/eji.1830210202. PMID: 1847874. 4: Smith BJ, Zupan LA, Hu JK, Diters RW, Gibson GW, Norton JN. Characterization of the effects of tebufelone on hepatic cytochromes P450 in the beagle dog. Drug Metab Dispos. 1996 May;24(5):523-8. PMID: 8723731. 5: Weisman SM, Doyle MJ, Wehmeyer KR, Hynd BA, Eichhold TH, Clear RM, Coggeshall CW, Kuhlenbeck DL. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Agents Actions. 1994 May;41(3-4):156-63. doi: 10.1007/BF02001910. PMID: 7942323. 6: Cruze CA, Kelm GR, Meredith MP. Interspecies scaling of tebufelone pharmacokinetic data and application to preclinical toxicology. Pharm Res. 1995 Jun;12(6):895-901. doi: 10.1023/a:1016273306956. PMID: 7667197. 7: Dobson RL, Dirr MK, Merkt BL. Automated gas chromatography/tandem mass spectrometry with on-line chemical derivatization for the determination of tebufelone and two metabolites in human plasma. J Mass Spectrom. 1997 Dec;32(12):1290-8. doi: 10.1002/(SICI)1096-9888(199712)32:12<1290::AID- JMS587>3.0.CO;2-L. PMID: 9423282. 8: Doyle MJ, Eichhold TH, Loomans ME, Farmer RW, Kelm GR. Comparison of tebufelone distribution in rat blood plasma and inflamed and noninflamed tissues following peroral and intravenous administration. J Pharm Sci. 1993 Aug;82(8):847-50. doi: 10.1002/jps.2600820819. PMID: 8377126. 9: Wehmeyer KR, Knight PM, Parry RC. Evaluation of a benchtop ion trap gas chromatographic-tandem mass spectrometric instrument for the analysis of a model drug, tebufelone, in plasma using a stable-isotope internal standard. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):53-9. doi: 10.1016/0378-4347(95)00417-3. PMID: 8852044. 10: Dobson RL, Kelm GR, Neal DM. Automated gas chromatography/tandem mass spectrometry assay for tebufelone and a 13C,(18)O-labeled analog in plasma: applicabilityto absolute bioavailability determination. Biol Mass Spectrom. 1994 Feb;23(2):75-81. doi: 10.1002/bms.1200230206. PMID: 8123692.

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