Synonym
MCI-727; MCI 727; MCI727
IUPAC/Chemical Name
Ethanone, 2-(4-methyl-1-piperazinyl)-1-(4-(2-phenylethyl)phenyl)-, oxime, monohydrochloride, (Z)-
InChi Key
GHQULUHUJBVDNH-QUABFQRHSA-N
InChi Code
InChI=1S/C21H27N3O.ClH/c1-23-13-15-24(16-14-23)17-21(22-25)20-11-9-19(10-12-20)8-7-18-5-3-2-4-6-18;/h2-6,9-12,25H,7-8,13-17H2,1H3;1H/b22-21+;
SMILES Code
Cl.CN1CCN(C\C(=N/O)\c2ccc(CCc3ccccc3)cc2)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
373.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Kawamura M, Yamazaki S, Tobe A, Watanabe S, Takeuchi T. Effects of MCI-727, a new anti-ulcer agent, on plasma secretin concentration in rats and dogs and pancreatic exocrine secretion in rats. Jpn J Pharmacol. 1991 Aug;56(4):513-22. doi: 10.1254/jjp.56.513. PMID: 1744991.
2. Tachibana I, Watanabe N, Shirohara H, Akiyama T, Nakano S, Otsuki M. Effects of MCI-727 on pancreatic exocrine secretion and acute pancreatitis in two experimental rat models. Pancreas. 1996 Mar;12(2):165-72. doi: 10.1097/00006676-199603000-00010. PMID: 8720664.
3. Yamazaki S, Kawamura M, Kitsukawa M, Ando K, Nitta I, Tobe A, Okabe S. Effects of MCI-727, a new antiulcer agent, on various gastric and duodenal lesions in experimental animals. Jpn J Pharmacol. 1991 Apr;55(4):415-24. doi: 10.1254/jjp.55.415. PMID: 1886287.
