BMS-753426 | CAS#1004536-52-0 | CCR2 Antagonist

MedKoo Cat#: 464774 | Name: BMS-753426

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-753426 is a potent and orally bioavailable antagonist of CCR2. Compared to previous clinical candidate BMS-741672, BMS-753426 showed significant improvements in pharmacokinetic properties, with lower clearance and higher oral bioavailability. Furthermore, BMS-753426 exhibited improved affinity for CCR5 and good activity in models of both monocyte migration and multiple sclerosis in the hCCR2 knock-in mouse.

Chemical Structure

BMS-753426

CAS#1004536-52-0

Theoretical Analysis

MedKoo Cat#: 464774

Name: BMS-753426

CAS#: 1004536-52-0

Chemical Formula: C25H33F3N6O2

Exact Mass: 506.2617

Molecular Weight: 506.57

Elemental Analysis: C, 59.28; H, 6.57; F, 11.25; N, 16.59; O, 6.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BMS-753426; BMS753426; BMS 753426;

IUPAC/Chemical Name

N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-((6-(trifluoromethyl)quinazolin-4-yl)amino)pyrrolidin-1-yl)cyclohexyl)acetamide

InChi Key

QAPTWHXHEYAIKG-RCOXNQKVSA-N

InChi Code

InChI=1S/C25H33F3N6O2/c1-14(35)31-20-12-16(33-24(2,3)4)6-8-21(20)34-10-9-19(23(34)36)32-22-17-11-15(25(26,27)28)5-7-18(17)29-13-30-22/h5,7,11,13,16,19-21,33H,6,8-10,12H2,1-4H3,(H,31,35)(H,29,30,32)/t16-,19+,20-,21+/m1/s1

SMILES Code

[H]N(C(C)=O)[C@@H]1C[C@H](N([H])C(C)(C)C)CC[C@@H]1N2CC[C@H](N(C3=NC=NC4=C3C=C(C(F)(F)F)C=C4)[H])C2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 506.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.