L-163491 | CAS# 170969-73-0 | partial agonist of angiotensin II receptor type 1

MedKoo Cat#: 414281 | Name: L-163491

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-163491 is a drug which acts as a partial agonist of angiotensin II receptor type 1, and with lower affinity as an agonist of angiotensin II receptor type 2, mimicking the action of angiotensin II. Its practical applications to date have been limited to scientific research into the function of the angiotensin receptor system, but it has been suggested as a potential therapeutic agent for the treatment of inflammation of the lungs associated with certain viral diseases such as COVID-19.

Chemical Structure

L-163491

CAS#170969-73-0

Theoretical Analysis

MedKoo Cat#: 414281

Name: L-163491

CAS#: 170969-73-0

Chemical Formula: C36H40N4O5S

Exact Mass: 640.2719

Molecular Weight: 640.79

Elemental Analysis: C, 67.48; H, 6.29; N, 8.74; O, 12.48; S, 5.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

L-163491; L163491; L 163491

IUPAC/Chemical Name

5,7-Dimethyl-2-ethyl-3-((2'-((butyloxycarbonyl) aminosulfonyl)-5'-(3-methyoxybenzyl)-(1,1'-biphenyl)-4-yl)methyl)-3H-imidazo(4,5-b)pyridine

InChi Key

SRCIRAKBWHTYIX-UHFFFAOYSA-N

InChi Code

InChI=1S/C36H40N4O5S/c1-6-8-18-45-36(41)39-46(42,43)32-17-14-28(20-27-10-9-11-30(21-27)44-5)22-31(32)29-15-12-26(13-16-29)23-40-33(7-2)38-34-24(3)19-25(4)37-35(34)40/h9-17,19,21-22H,6-8,18,20,23H2,1-5H3,(H,39,41)

SMILES Code

COC1=CC(CC2=CC=C(S(=O)(NC(OCCCC)=O)=O)C(C3=CC=C(CN4C(CC)=NC5=C(C)C=C(C)N=C54)C=C3)=C2)=CC=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 640.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: De Witt BJ, Garrison EA, Champion HC, Kadowitz PJ. L-163,491 is a partial angiotensin AT(1) receptor agonist in the hindquarters vascular bed of the cat. Eur J Pharmacol. 2000 Sep 15;404(1-2):213-9. doi: 10.1016/s0014-2999(00)00612-9. PMID: 10980281. 2: Kaye AD, Nossaman BD, Kivlighn S, Ibrahim IN, De Witt BJ, Kadowitz PJ. Responses to L-163,491, a nonpeptide angiotensin II mimic, in the pulmonary vascular bed of the cat. Eur J Pharmacol. 1995 Dec 12;287(2):163-8. doi: 10.1016/0014-2999(95)00486-6. PMID: 8749030. 3: Kaye AD, Nossaman BD, Margolis MA, Ibrahim IN, Kivlighn SD, Smith DE, Kadowitz PJ. Responses to a nonpeptide angiotensin receptor agonist, L 163491, in the feline pulmonary vascular bed. Life Sci. 1995;57(20):PL301-5. doi: 10.1016/0024-3205(95)02169-j. PMID: 7475924.