MedKoo Cat#: 414280 | Name: L-159884

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-159884 is a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging

Chemical Structure

L-159884
L-159884
CAS#174844-73-6

Theoretical Analysis

MedKoo Cat#: 414280

Name: L-159884

CAS#: 174844-73-6

Chemical Formula: C31H30N4O4S

Exact Mass: 554.1988

Molecular Weight: 554.67

Elemental Analysis: C, 67.13; H, 5.45; N, 10.10; O, 11.54; S, 5.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
L-159884; L159884; L 159884
IUPAC/Chemical Name
N-((4'-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-[1,1'-biphenyl]-2-yl)sulfonyl)-4-methoxybenzamide
InChi Key
IRQSDNILKLKJIU-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H30N4O4S/c1-5-28-33-29-20(2)18-21(3)32-30(29)35(28)19-22-10-12-23(13-11-22)26-8-6-7-9-27(26)40(37,38)34-31(36)24-14-16-25(39-4)17-15-24/h6-18H,5,19H2,1-4H3,(H,34,36)
SMILES Code
CCc(n1)n(Cc2ccc(c3c(S(=O)(NC(c4ccc(OC)cc4)=O)=O)cccc3)cc2)c5c1c(C)cc(C)n5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 554.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Szabo Z, Speth RC, Brown PR, Kerenyi L, Kao PF, Mathews WB, Ravert HT, Hilton J, Rauseo P, Dannals RF, Zheng W, Lee S, Sandberg K. Use of positron emission tomography to study AT1 receptor regulation in vivo. J Am Soc Nephrol. 2001 Jul;12(7):1350-1358. doi: 10.1681/ASN.V1271350. PMID: 11423564. 2: Hilton J, Yokoi F, Dannals RF, Ravert HT, Szabo Z, Wong DF. Column-switching HPLC for the analysis of plasma in PET imaging studies. Nucl Med Biol. 2000 Aug;27(6):627-30. doi: 10.1016/s0969-8051(00)00125-6. PMID: 11056380. 3: Szabo Z, Kao PF, Burns HD, Gibson RE, Hamill TG, Ravert HT, Kim SE, Mathews WB, Musachio JL, Scheffel U, Dannals RF. Investigation of angiotensin II/AT1 receptors with carbon-11-L-159,884: a selective AT1 antagonist. J Nucl Med. 1998 Jul;39(7):1209-13. PMID: 9669396. 4: Hamill TG, Burns HD, Dannals RF, Mathews WB, Musachio JL, Ravert HT, Naylor EM. Development of [11C]L-159,884: a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging. Appl Radiat Isot. 1996 Feb;47(2):211-8. doi: 10.1016/0969-8043(95)00273-1. PMID: 8852629. 5: Owonikoko TK, Fabucci ME, Brown PR, Nisar N, Hilton J, Mathews WB, Ravert HT, Rauseo P, Sandberg K, Dannals RF, Szabo Z. In vivo investigation of estrogen regulation of adrenal and renal angiotensin (AT1) receptor expression by PET. J Nucl Med. 2004 Jan;45(1):94-100. PMID: 14734680; PMCID: PMC1828744. 6: Kim SE, Scheffel U, Szabo Z, Burns HD, Gibson RE, Ravert HT, Mathews WB, Hamill TG, Dannals RF. In vivo labeling of angiotensin II receptors with a carbon-11-labeled selective nonpeptide antagonist. J Nucl Med. 1996 Feb;37(2):307-11. PMID: 8667067.