KW 5092 | CAS# 135017-85-5 | stimulator of gastrointestinal motility

MedKoo Cat#: 414273 | Name: KW 5092

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KW 5092 is a stimulator of gastrointestinal motility.

Chemical Structure

KW 5092

CAS#135017-85-5

Theoretical Analysis

MedKoo Cat#: 414273

Name: KW 5092

CAS#: 135017-85-5

Chemical Formula: C23H30N6O5

Exact Mass: 470.2278

Molecular Weight: 470.53

Elemental Analysis: C, 58.71; H, 6.43; N, 17.86; O, 17.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KW 5092; KW5092; KW-5092

IUPAC/Chemical Name

(1-(2-(((5-(piperidinomethyl)-2-furanyl)methyl)amino)ethyl)-2-imidazolidinylidene)propanedinitrile fumarate

InChi Key

ULJCVCIVEVXIKD-WLHGVMLRSA-N

InChi Code

InChI=1S/C19H26N6O.C4H4O4/c20-12-16(13-21)19-23-7-11-25(19)10-6-22-14-17-4-5-18(26-17)15-24-8-2-1-3-9-24;5-3(6)1-2-4(7)8/h4-5,22-23H,1-3,6-11,14-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1+

SMILES Code

N#C/C(C#N)=C1NCCN/1CCNCC2=CC=C(CN3CCCCC3)O2.O=C(O)/C=C/C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 470.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kishibayashi N, Tomaru A, Ichikawa S, Kitazawa T, Shuto K, Ishii A, Karasawa A. Enhancement by KW-5092, a novel gastroprokinetic agent, of the gastrointestinal motor activity in dogs. Jpn J Pharmacol. 1994 Jun;65(2):131-42. doi: 10.1254/jjp.65.131. PMID: 7967226. 2: Kishibayashi N, Ishii A, Karasawa A. Enhancement by KW-5092, a novel gastroprokinetic agent, of the release of acetylcholine from enteric neurons in the guinea pig ileum. Jpn J Pharmacol. 1994 Apr;64(4):289-95. doi: 10.1254/jjp.64.289. PMID: 8057530. 3: Kishibayashi N, Ishii A, Karasawa A. Inhibitory effects of KW-5092, a novel gastroprokinetic agent, on the activity of acetylcholinesterase in guinea pig ileum. Jpn J Pharmacol. 1994 Dec;66(4):397-403. doi: 10.1254/jjp.66.397. PMID: 7723214. 4: Kojima S. KW-5092, a novel gastrokinetic agent, facilitates luminal serotonin release from the guinea-pig colon. Eur J Pharmacol. 1999 Jun 11;374(1):113-5. doi: 10.1016/s0014-2999(99)00336-2. PMID: 10422647. 5: Takasaki K, Kishibayashi N, Ishii A, Karasawa A. Effects of KW-5092, a novel gastroprokinetic agent, on the delayed colonic propulsion in rats. Jpn J Pharmacol. 1994 May;65(1):67-71. doi: 10.1254/jjp.65.67. PMID: 8089932. 6: Kishibayashi N, Karasawa A. Stimulating effects of KW-5092, a novel gastroprokinetic agent, on the gastric emptying, small intestinal propulsion and colonic propulsion in rats. Jpn J Pharmacol. 1995 Jan;67(1):45-50. doi: 10.1254/jjp.67.45. PMID: 7745844. 7: Makimoto N, Yamazaki A, Kobayashi H, Kishibayashi N, Ohmori K, Furuichi A, Kanematsu T, Taniyama K. Acceleration by KW-5092 of intestinal motility associated with acetylcholine release in vivo. Jpn J Pharmacol. 2000 Jun;83(2):157-60. doi: 10.1254/jjp.83.157. PMID: 10928330. 8: Kishibayashi N, Karasawa A. Effects of KW-5092, a novel gastroprokinetic agent, on intestinal water and electrolyte transport in rats. Biol Pharm Bull. 1995 Dec;18(12):1671-5. doi: 10.1248/bpb.18.1671. PMID: 8787786. 9: Kishibayashi N, Yokoyama T, Karasawa A. Enhancement of defecation and distal colonic motor activity by KW-5092, a novel gastroprokinetic agent, in rats. Arch Int Pharmacodyn Ther. 1995 Mar-Apr;329(2):295-306. PMID: 8540768. 10: Yamada S, Fujii T, Kawashima K. Oral administration of KW-5092, a novel gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release enhancing activities, causes a dose-dependent increase in the blood acetylcholine content of beagle dogs. Neurosci Lett. 1997 Mar 28;225(1):25-8. doi: 10.1016/s0304-3940(97)00188-2. PMID: 9143009.