MC-3377 | CAS# 1438850-02-2 | Biochemical

MedKoo Cat#: 576925 | Name: MC-3377

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MC-3377 is an auristatin cytotoxic agent LP2 primarily used in antibody-drug conjugation.

Chemical Structure

MC-3377

CAS#1438850-02-2

Theoretical Analysis

MedKoo Cat#: 576925

Name: MC-3377

CAS#: 1438850-02-2

Chemical Formula: C48H74N6O11

Exact Mass: 910.5416

Molecular Weight: 911.15

Elemental Analysis: C, 63.27; H, 8.19; N, 9.22; O, 19.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

LP2; MC-3377; MC 3377; MC3377; MC-PF-06463377

IUPAC/Chemical Name

((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-(2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylhexanamido)-2-methylpropanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine

InChi Key

KXMYSYKVFYTFMW-UEDHTMJLSA-N

InChi Code

1S/C48H74N6O11/c1-12-31(4)42(51(8)45(60)41(30(2)3)50-47(63)48(6,7)52(9)37(55)23-17-14-18-26-54-38(56)24-25-39(54)57)36(64-10)29-40(58)53-27-19-22-35(53)43(65-11)32(5)44(59)49-34(46(61)62)28-33-20-15-13-16-21-33/h13,15-16,20-21,24-25,30-32,34-36,41-43H,12,14,17-19,22-23,26-29H2,1-11H3,(H,49,59)(H,50,63)(H,61,62)/t31-,32+,34-,35-,36+,41-,42-,43+/m0/s1

SMILES Code

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)N(C)C(=O)CCCCCN3C(=O)C=CC3=O)C(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 911.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder WB, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC. Novel Anti-TM4SF1 Antibody-Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature. Mol Cancer Ther. 2015 Aug;14(8):1868-76. doi: 10.1158/1535-7163.MCT-15-0188. Epub 2015 Jun 18. PMID: 26089370.