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MedKoo Cat#: 414270 | Name: KRM 1687

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KRM 1687 is a biochemical with antimycobacterial activity.

Chemical Structure

KRM 1687
KRM 1687
CAS#133698-17-6

Theoretical Analysis

MedKoo Cat#: 414270

Name: KRM 1687

CAS#: 133698-17-6

Chemical Formula: C51H61N4O13

Exact Mass: 937.4235

Molecular Weight: 938.06

Elemental Analysis: C, 65.30; H, 6.55; N, 5.97; O, 22.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KRM 1687; KRM1687; KRM-1687
IUPAC/Chemical Name
Rifamycin VIII, 1',4-didehydro-1-deoxy-1,4-dihydro-3'-hydroxy-5'-(4-(1-methylpropyl)-1-piperazinyl)-1-oxo-, (5'(S))-
InChi Key
LIERTHOGCYDXMI-QQMYZPBHSA-N
InChi Code
InChI=1S/C51H64N4O13/c1-12-26(4)54-17-19-55(20-18-54)32-22-33(57)39-35(23-32)67-48-40(52-39)36-37-44(60)30(8)47-38(36)49(62)51(10,68-47)65-21-16-34(64-11)27(5)46(66-31(9)56)29(7)43(59)28(6)42(58)24(2)14-13-15-25(3)50(63)53-41(48)45(37)61/h13-16,21-24,26-29,34,42-43,46,57-60H,12,17-20H2,1-11H3,(H,53,63)/b14-13+,21-16+,25-15-/t24-,26-,27+,28+,29+,34-,42-,43+,46+,51-/m0/s1
SMILES Code
CC[C@@H](N1CCN(c2cc3c(N=C4C(O3)=C5NC(/C(C)=C\C=C\[C@@H](c(O)c(C)c([C@H]([C@@H]([C@@H]([C@H](/C=C/O[C@]6(Oc7c(C6=O)c4c(C5=O)c(O)c7C)C)OC)C)OC(C)=O)C)O)C)=O)c(O)c2)CC1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 938.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Saito H, Tomioka H, Sato K, Emori M, Yamane T, Yamashita K, Hosoe K, Hidaka T. In vitro antimycobacterial activities of newly synthesized benzoxazinorifamycins. Antimicrob Agents Chemother. 1991 Mar;35(3):542-7. doi: 10.1128/AAC.35.3.542. PMID: 2039206; PMCID: PMC245047. 2: Dhople AM, Ibanez MA. The in-vitro activities of novel benzoxazinorifamycins against Mycobacterium leprae. J Antimicrob Chemother. 1995 Apr;35(4):463-71. doi: 10.1093/jac/35.4.463. PMID: 7628981. 3: Kuze F. [Antimycobacterial activities of rifamycin derivatives]. Kekkaku. 1991 Oct;66(10):679-85. Japanese. PMID: 1960916. 4: Dhople AM. Comparative in vitro activities of rifamycin analogues against Mycobacterium leprae. Indian J Lepr. 1997 Oct-Dec;69(4):377-84. PMID: 9474513.

View History

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