KP 10614 | CAS# 130273-99-3 | prostacyclin analog

MedKoo Cat#: 414264 | Name: KP 10614

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KP 10614 is a new prostacyclin analog that inhibits platelet-polymorphonuclear leukocyte interaction.

Chemical Structure

KP 10614

CAS#130273-99-3

Theoretical Analysis

MedKoo Cat#: 414264

Name: KP 10614

CAS#: 130273-99-3

Chemical Formula: C25H30O4

Exact Mass: 394.2144

Molecular Weight: 394.51

Elemental Analysis: C, 76.11; H, 7.67; O, 16.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

KP 10614; KP10614; KP-10614

IUPAC/Chemical Name

4-Penenoic acid, 5-(1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-(3-hydroxy-4-methyl-1-nonen-6-ynyl)-2-pentalenyl)-, (3aS-(2(Z),3aalpha,5beta,6alpha(1E,3R*,4R*),6aalpha))-

InChi Key

APZCSVJPIMEACH-OWXQQVNESA-N

InChi Code

InChI=1S/C25H30O4/c1-3-4-5-7-16(2)23(26)11-10-21-22-14-19(13-20(22)15-24(21)27)17-8-6-9-18(12-17)25(28)29/h6,8-13,16,20-24,26-27H,3,7,14-15H2,1-2H3,(H,28,29)/b11-10-/t16-,20-,21+,22-,23+,24+/m0/s1

SMILES Code

O=C(O)C1=CC(C2=C[C@@]3([H])C[C@@H](O)[C@H](/C=C\[C@@H](O)[C@@H](C)CC#CCC)[C@@]3([H])C2)=CC=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 394.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kanayama T, Kimura Y, Mizogami S. A new prostacyclin analog, KP-10614, inhibits platelet-polymorphonuclear leukocyte interaction and limits experimental infarct size in rat heart. J Pharmacol Exp Ther. 1993 Jul;266(1):344-9. PMID: 7687292. 2: Kanayama T, Kimura Y, Iseki K, Hayashi Y, Tamao Y, Mizogami S. Antithrombotic effects of KP-10614, a novel and stable prostacyclin (PGI2) analog. J Pharmacol Exp Ther. 1990 Dec;255(3):1210-7. PMID: 1702154. 3: Kanayama T, Kimura Y, Tamao Y, Mizogami S. Beneficial effects of a new prostacyclin analogue, KP-10614, on acute myocardial infarction in rats. J Cardiovasc Pharmacol. 1992 Oct;20(4):630-7. doi: 10.1097/00005344-199210000-00017. PMID: 1280720.