GW117 | CAS#unknown | 5-HT2C receptor antagonist/MT1/MT2 receptor agonist

MedKoo Cat#: 464754 | Name: GW117

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW117 is a novel serotonin (5-HT2C) receptor antagonist and melatonin (MT1/MT2) receptor agonist with potential antidepressant-like activity in rodents.

Chemical Structure

GW117

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464754

Name: GW117

CAS#: unknown

Chemical Formula: C15H13D3ClNO2

Exact Mass: 280.1058

Molecular Weight: 280.77

Elemental Analysis: C, 64.17; H, 6.82; Cl, 12.63; N, 4.99; O, 11.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GW117; GW 117; GW-117;

IUPAC/Chemical Name

N-(2-(6-chloro-7-(methoxy-d3)naphthalen-1-yl)ethyl)acetamide

InChi Key

KNYFIWBFKFDCTJ-BMSJAHLVSA-N

InChi Code

InChI=1S/C15H16ClNO2/c1-10(18)17-7-6-11-4-3-5-12-8-14(16)15(19-2)9-13(11)12/h3-5,8-9H,6-7H2,1-2H3,(H,17,18)/i2D3

SMILES Code

CC(NCCC1=C2C=C(OC([2H])([2H])[2H])C(Cl)=CC2=CC=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 280.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gao N, Zheng W, Murezati T, Gu W, Li X, Jin Z. GW117: A novel serotonin (5-HT2C ) receptor antagonist and melatonin (MT1 /MT2 ) receptor agonist with potential antidepressant-like activity in rodents. CNS Neurosci Ther. 2021 Jun;27(6):702-713. doi: 10.1111/cns.13630. Epub 2021 Mar 1. PMID: 33650297; PMCID: PMC8111499. 2: Yang Q, Zhou X, Li J, Ma Y, Lu L, Xiong J, Xu P, Li Y, Chen Y, Gu W, Xue M, Jin Z, Li X. Sub-Acute Oral Toxicity of a Novel Derivative of Agomelatine in Rats in a Sex-Dependent Manner. Front Pharmacol. 2019 Mar 19;10:242. doi: 10.3389/fphar.2019.00242. PMID: 30941037; PMCID: PMC6433965.