Synonym
PD-159206; PD159206; PD 159206; CI 1013; CI-1013; CI1013; DIBA 4;
IUPAC/Chemical Name
N,N'-[Dithiobis(2,1-phenylenecarbonyl)]bis[isoleucine]
InChi Key
SUQDXZBTWJQATJ-QDGJQWLKSA-N
InChi Code
InChI=1S/C26H32N2O6S2/c1-5-15(3)21(25(31)32)27-23(29)17-11-7-9-13-19(17)35-36-20-14-10-8-12-18(20)24(30)28-22(26(33)34)16(4)6-2/h7-16,21-22H,5-6H2,1-4H3,(H,27,29)(H,28,30)(H,31,32)(H,33,34)/t15-,16-,21-,22-/m0/s1
SMILES Code
O=C(N[C@@H]([C@@H](C)CC)C(O)=O)C1=CC=CC=C1SSC2=CC=CC=C2C(N[C@@H]([C@@H](C)CC)C(O)=O)=O
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
PD-159206 is a nucleocapsid inhibitor.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
532.67
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Domagala JM, Gogliotti R, Sanchez JP, Stier MA, Musa K, Song Y, Loo J, Reily M, Tummino P, Harvey P, Hupe D, Sharmeen L, Mack D, Scholten J, Saunders J, McQuade T. 2,2'-Dithiobisbenzamides and 2-benzisothiazolones, two new classes of antiretroviral agents: SAR and mechanistic considerations. Drug Des Discov. 1997 May;15(1):49-61. PMID: 9332831.
In vitro protocol:
1. Domagala JM, Gogliotti R, Sanchez JP, Stier MA, Musa K, Song Y, Loo J, Reily M, Tummino P, Harvey P, Hupe D, Sharmeen L, Mack D, Scholten J, Saunders J, McQuade T. 2,2'-Dithiobisbenzamides and 2-benzisothiazolones, two new classes of antiretroviral agents: SAR and mechanistic considerations. Drug Des Discov. 1997 May;15(1):49-61. PMID: 9332831.
In vivo protocol:
1. Domagala JM, Gogliotti R, Sanchez JP, Stier MA, Musa K, Song Y, Loo J, Reily M, Tummino P, Harvey P, Hupe D, Sharmeen L, Mack D, Scholten J, Saunders J, McQuade T. 2,2'-Dithiobisbenzamides and 2-benzisothiazolones, two new classes of antiretroviral agents: SAR and mechanistic considerations. Drug Des Discov. 1997 May;15(1):49-61. PMID: 9332831.
1: Zhao X, Xu H, Li Y, Ma R, Qi Y, Zhang M, Guo C, Sun Z, Li Y. Proteomic profiling reveals dysregulated mitochondrial complex subunits responsible for myocardial toxicity induced by SiNPs. Sci Total Environ. 2023 Jan 20;857(Pt 1):159206. doi: 10.1016/j.scitotenv.2022.159206. Epub 2022 Oct 2. PMID: 36198348.
2: Poddalgoda D, Macey K, Hancock S. Derivation of biomonitoring equivalents (BE values) for zinc. Regul Toxicol Pharmacol. 2019 Aug;106:178-186. doi: 10.1016/j.yrtph.2019.04.018. Epub 2019 May 4. PMID: 31063796.
3: Ochiai A, Naya Y, Soh J, Ishida Y, Mizutani Y, Kawauchi A, Fujiwara T, Miki T. Efficacy of sildenafil as the first-step therapeutic tool for Japanese patients with erectile dysfunction. Int J Impot Res. 2005 Jul-Aug;17(4):339-42. doi: 10.1038/sj.ijir.3901318. PMID: 15829991.
4: Sharmeen L, McQuade T, Heldsinger A, Gogliotti R, Domagala J, Gracheck S. Inhibition of the early phase of HIV replication by an isothiazolone, PD 161374. Antiviral Res. 2001 Feb;49(2):101-14. doi: 10.1016/s0166-3542(00)00143-1. PMID: 11248362.
5: Domagala JM, Gogliotti R, Sanchez JP, Stier MA, Musa K, Song Y, Loo J, Reily M, Tummino P, Harvey P, Hupe D, Sharmeen L, Mack D, Scholten J, Saunders J, McQuade T. 2,2'-Dithiobisbenzamides and 2-benzisothiazolones, two new classes of antiretroviral agents: SAR and mechanistic considerations. Drug Des Discov. 1997 May;15(1):49-61. PMID: 9332831.
