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MedKoo Cat#: 464749 | Name: Herbacetin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Herbacetin is a natural product that acts as a selective inhibitor of ornithine decarboxylase (ODC). It inhibits recombinant and HCT116 and HT29 colon cancer cell-derived ODC in a dose-dependent manner while having no effect on 13 tested kinases or S-adenosylmethionine decarboxylase in vitro. Herbacetin suppresses anchorage-independent growth, activation of activator protein-1 (AP-1), a MAP kinase transcription factor, and phosphorylation of ERK1/2 and p90RSK in vitro. It suppresses HCT116 xenograft tumor growth in mice without significant body weight loss when administered i.p. or orally. Herbacetin also inhibits acetylcholinesterase (AChE; IC50 = 1.37 μM) in vitro.

Chemical Structure

Herbacetin
Herbacetin
CAS#527-95-7

Theoretical Analysis

MedKoo Cat#: 464749

Name: Herbacetin

CAS#: 527-95-7

Chemical Formula: C15H10O7

Exact Mass: 302.0427

Molecular Weight: 302.24

Elemental Analysis: C, 59.61; H, 3.34; O, 37.05

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 600.00 2 Weeks
25mg USD 1,100.00 2 Weeks
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Related CAS #
No Data
Synonym
Herbacetin; Isoarticulatidin; 8-hydroxy Kaempferol;
IUPAC/Chemical Name
3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
InChi Key
ZDOTZEDNGNPOEW-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)14-13(21)12(20)10-8(17)5-9(18)11(19)15(10)22-14/h1-5,16-19,21H
SMILES Code
O=C(C1=C(C(O)=C(O)C=C1O)O2)C(O)=C2C3=CC=C(O)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 30.0 99.26
DMSO 30.0 99.26
DMSO:PBS(pH 7.2) (1:4) 1.0 3.31
Ethanol 2.0 6.62
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 302.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tallei TE, Tumilaar SG, Niode NJ, Fatimawali, Kepel BJ, Idroes R, Effendi Y, Sakib SA, Emran TB. Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study. Scientifica (Cairo). 2020 Dec 23;2020:6307457. doi: 10.1155/2020/6307457. PMID: 33425427; PMCID: PMC7773461. 2: Li L, Ye J, Li H, Shi Q. Characterization of Metabolites and Transcripts Involved in Flower Pigmentation in Primula vulgaris. Front Plant Sci. 2020 Nov 20;11:572517. doi: 10.3389/fpls.2020.572517. PMID: 33329630; PMCID: PMC7714730. 3: Zhou W, Chen K, Lu Q, Luo Y, Zhang C, Zheng Y, Zhuo Z, Guo K, Wang J, Chen H, Sha W. The Protective Effect of Rosavin from Rhodiola rosea on Radiation-Induced Intestinal Injury. Chem Biodivers. 2020 Dec;17(12):e2000652. doi: 10.1002/cbdv.202000652. Epub 2020 Nov 26. PMID: 33089958. 4: Adhikari B, Marasini BP, Rayamajhee B, Bhattarai BR, Lamichhane G, Khadayat K, Adhikari A, Khanal S, Parajuli N. Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review. Phytother Res. 2021 Mar;35(3):1298-1312. doi: 10.1002/ptr.6893. Epub 2020 Oct 9. PMID: 33037698; PMCID: PMC7675695. 5: Chen X, Xun D, Zheng R, Zhao L, Lu Y, Huang J, Wang R, Wang Y. Deep-Learning- Assisted Assessment of DNA Damage Based on Foci Images and Its Application in High-Content Screening of Lead Compounds. Anal Chem. 2020 Oct 20;92(20):14267-14277. doi: 10.1021/acs.analchem.0c03741. Epub 2020 Sep 28. PMID: 32986405. 6: Solnier J, Fladerer JP. Flavonoids: A complementary approach to conventional therapy of COVID-19? Phytochem Rev. 2020 Sep 18:1-23. doi: 10.1007/s11101-020-09720-6. Epub ahead of print. PMID: 32982616; PMCID: PMC7500502. 7: Zhong L, Peng L, Fu J, Zou L, Zhao G, Zhao J. Phytochemical, Antibacterial and Antioxidant Activity Evaluation of Rhodiola crenulata. Molecules. 2020 Aug 12;25(16):3664. doi: 10.3390/molecules25163664. PMID: 32806502; PMCID: PMC7464835. 8: Jo S, Kim S, Kim DY, Kim MS, Shin DH. Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1539-1544. doi: 10.1080/14756366.2020.1801672. PMID: 32746637; PMCID: PMC7470085. 9: Proença C, Oliveira A, Freitas M, Ribeiro D, Sousa JLC, Ramos MJ, Silva AMS, Fernandes PA, Fernandes E. Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase. J Nat Prod. 2020 May 22;83(5):1541-1552. doi: 10.1021/acs.jnatprod.0c00014. Epub 2020 May 4. PMID: 32364726. 10: Jo S, Kim S, Shin DH, Kim MS. Inhibition of SARS-CoV 3CL protease by flavonoids. J Enzyme Inhib Med Chem. 2020 Dec;35(1):145-151. doi: 10.1080/14756366.2019.1690480. PMID: 31724441; PMCID: PMC6882434. 11: Jo S, Kim H, Kim S, Shin DH, Kim MS. Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors. Chem Biol Drug Des. 2019 Dec;94(6):2023-2030. doi: 10.1111/cbdd.13604. Epub 2019 Sep 12. PMID: 31436895; PMCID: PMC7162010. 12: Xiao YC, Shi ZF, Yan CQ, Tang QX, Zhao MX, Liu LT, Huang QS, Ye L, Xu K, Ke X. Isolation, X-ray crystal structure of the new diterpene and identification of others lignans and flavonoids from the fresh needles of Pinus massoniana. J Asian Nat Prod Res. 2020 Aug;22(8):707-715. doi: 10.1080/10286020.2019.1642331. Epub 2019 Aug 1. PMID: 31368350. 13: Péter Zomborszki Z, Kúsz N, Csupor D, Peschel W. Rhodiosin and herbacetin in Rhodiola rosea preparations: additional markers for quality control? Pharm Biol. 2019 Dec;57(1):295-305. doi: 10.1080/13880209.2019.1577460. PMID: 31356124; PMCID: PMC6711108. 14: Singh P, Singh VK, Singh AK. Molecular docking analysis of candidate compoundsderived from medicinal plants with type 2 diabetes mellitus targets. Bioinformation. 2019 Mar 15;15(3):179-188. doi: 10.6026/97320630015179. PMID: 31354193; PMCID: PMC6637395. 15: Li L, Fan P, Chou H, Li J, Wang K, Li H. Herbacetin suppressed MMP9 mediated angiogenesis of malignant melanoma through blocking EGFR-ERK/AKT signaling pathway. Biochimie. 2019 Jul;162:198-207. doi: 10.1016/j.biochi.2019.05.003. Epub 2019 May 8. PMID: 31075281. 16: Cai P, Cai T, Li X, Fan L, Chen G, Yu B, Liu T. Herbacetin treatment remitted LPS induced inhibition of osteoblast differentiation through blocking AKT/NF-κB signaling pathway. Am J Transl Res. 2019 Feb 15;11(2):865-874. PMID: 30899386; PMCID: PMC6413242. 17: Veeramani C, Alsaif MA, Al-Numair KS. Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid- regulating enzymes. Chem Biol Interact. 2018 May 25;288:49-56. doi: 10.1016/j.cbi.2018.04.009. Epub 2018 Apr 11. PMID: 29653099. 18: Kim DJ, Lee MH, Liu K, Lim DY, Roh E, Chen H, Kim SH, Shim JH, Kim MO, Li W, Ma F, Fredimoses M, Bode AM, Dong Z. Herbacetin suppresses cutaneous squamous cell carcinoma and melanoma cell growth by targeting AKT and ODC. Carcinogenesis. 2017 Oct 26;38(11):1136-1146. doi: 10.1093/carcin/bgx082. PMID: 29029040; PMCID: PMC5862242. 19: Li FJ, Liu Y, Yuan Y, Yang B, Liu ZM, Huang LQ. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of Rhodiola crenulata using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532. doi: 10.1016/j.ijbiomac.2017.06.066. Epub 2017 Jun 16. PMID: 28625836. 20: Hyuga S. [The Pharmacological Actions of Ephedrine Alkaloids-free Ephreda Herb Extract and Preparation for Clinical Application]. Yakugaku Zasshi. 2017;137(2):179-186. Japanese. doi: 10.1248/yakushi.16-00233-4. PMID: 28154329.

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