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MedKoo Cat#: 414238 | Name: KF-25706

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KF-25706 is an oxime derivative of the macrocyclic antifungal antibiotic, radicicol, which was being developed as an anticancer agent.

Chemical Structure

KF-25706
KF-25706
CAS#184537-25-5

Theoretical Analysis

MedKoo Cat#: 414238

Name: KF-25706

CAS#: 184537-25-5

Chemical Formula: C18H18ClNO6

Exact Mass: 379.0823

Molecular Weight: 379.79

Elemental Analysis: C, 56.93; H, 4.78; Cl, 9.33; N, 3.69; O, 25.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KF-25706; KF25706; KF 25706
IUPAC/Chemical Name
6H-Oxireno(E)(2)benzoxacyclotetradecin-6,12(7H)-dione, 8-chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-, 6-oxime, (1aS,2Z,4E,14R,15aS)-
InChi Key
PXFCVALKVVALQA-FDUOYDKLSA-N
InChi Code
InChI=1S/C18H18ClNO6/c1-9-6-15-14(26-15)5-3-2-4-10(20-24)7-11-16(18(23)25-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22,24H,6-7H2,1H3/b4-2+,5-3-,20-10-/t9-,14+,15+/m1/s1
SMILES Code
O=C(O[C@H](C)C[C@@](O1)([H])[C@]1([H])/C=C\C=C\2)C3=C(O)C=C(O)C(Cl)=C3CC2=N\O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 379.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Soga S, Neckers LM, Schulte TW, Shiotsu Y, Akasaka K, Narumi H, Agatsuma T, Ikuina Y, Murakata C, Tamaoki T, Akinaga S. KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules. Cancer Res. 1999 Jun 15;59(12):2931-8. PMID: 10383157.