KF 4317 | CAS# 76805-48-6 | alpha- and beta 1-adrenoreceptor antagonist

MedKoo Cat#: 414231 | Name: KF 4317

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KF 4317 is a novel combined alpha- and beta 1-adrenoreceptor antagonist

Chemical Structure

KF 4317

CAS#76805-48-6

Theoretical Analysis

MedKoo Cat#: 414231

Name: KF 4317

CAS#: 76805-48-6

Chemical Formula: C21H28N2O3

Exact Mass: 356.2100

Molecular Weight: 356.47

Elemental Analysis: C, 70.76; H, 7.92; N, 7.86; O, 13.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KF 4317; KF-4317; KF4317

IUPAC/Chemical Name

Benzeneacetamide, 4-(2-hydroxy-3-((1-methyl-3-phenylpropyl)amino)propoxy)-

InChi Key

QUGGJYHUFSNFIO-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H28N2O3/c1-16(7-8-17-5-3-2-4-6-17)23-14-19(24)15-26-20-11-9-18(10-12-20)13-21(22)25/h2-6,9-12,16,19,23-24H,7-8,13-15H2,1H3,(H2,22,25)

SMILES Code

O=C(N)CC1=CC=C(OCC(O)CNC(C)CCC2=CC=CC=C2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 356.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Doggrell SA, Hughes EW. The effects of KF-4317, a novel combined alpha- and beta 1-adrenoreceptor antagonist, on the rat isolated right ventricle and aorta. J Auton Pharmacol. 1986 Mar;6(1):25-32. doi: 10.1111/j.1474-8673.1986.tb00627.x. PMID: 2870068. 2: Kubo K, Ikeda J, Nakamura J, Nakamizo N. Extremely long-acting antihypertensive effects of KF-4317, a alpha- and beta 1-adrenoceptor blocker. Arch Int Pharmacodyn Ther. 1985 Sep;277(1):140-60. PMID: 2865934. 3: Kubo K, Nakamura J, Karasawa A, Shuto K, Nakamizo N. Pharmacology of 4-(2-hydroxy-3-[(1-methyl-3-phenylpropyl)-amino]propoxy)benzeneacetamide (KF-4317). Arzneimittelforschung. 1983;33(7):926-31. PMID: 6138045. 4: Doggrell SA. Relaxant and beta 2-adrenoceptor blocking activities of labetalol, dilevalol, amosulalol and KF-4317 on the rat isolated aorta. J Pharm Pharmacol. 1988 Nov;40(11):812-5. doi: 10.1111/j.2042-7158.1988.tb05180.x. PMID: 2907566. 5: Takayanagi I, Koike K, Konno F, Hiruta T, Kusunoki M, Sato T, Toyoda J, Kizawa Y. Actions of 4-(2-hydroxy-3-[(1-methyl-3-phenylpropyl)amino]propoxy) benzeneacetamide (KF4317) and labetalol on alpha- and beta-adrenoceptors. Gen Pharmacol. 1986;17(6):651-3. doi: 10.1016/0306-3623(86)90295-8. PMID: 3028902.