Synonym
KB 5246; KB-5246; KB5246
IUPAC/Chemical Name
3H,8H-4-Oxa-1-thia-9b-azacyclopenta(cd)phenalene-9-carboxylic acid, 6-fluoro-5-(4-methyl-1-piperazinyl)-8-oxo-, monohydrochloride
InChi Key
DCZBGPOFHPVYER-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H16FN3O4S.ClH/c1-20-2-4-21(5-3-20)14-11(19)6-10-13-12-9(7-26-15(13)14)8-27-17(12)22(16(10)23)18(24)25;/h6,8H,2-5,7H2,1H3,(H,24,25);1H
SMILES Code
O=C(N(C1=O)C2=C3C(COC4=C3C1=CC(F)=C4N5CCN(C)CC5)=CS2)O.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
425.86
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kotera Y, Mitsuhashi S. In vitro and in vivo antibacterial activities of KB-5246, a new tetracyclic quinolone. Antimicrob Agents Chemother. 1989 Nov;33(11):1896-900. doi: 10.1128/AAC.33.11.1896. PMID: 2610501; PMCID: PMC172784.
2: Kotera Y, Inoue M, Mitsuhashi S. Activity of KB-5246 against outer membrane mutants of Escherichia coli and Salmonella typhimurium. Antimicrob Agents Chemother. 1990 Jul;34(7):1323-5. doi: 10.1128/AAC.34.7.1323. PMID: 2167038; PMCID: PMC175974.
3: Kotera Y, Inoue Y, Ohashi M, Ito K, Inoue M. Lack of effect of carbonyl cyanide m-chlorophenylhydrazone on KB-5246 accumulation by Staphylococcus aureus. Antimicrob Agents Chemother. 1992 Apr;36(4):883-5. doi: 10.1128/AAC.36.4.883. PMID: 1323957; PMCID: PMC189480.
4: Nakanishi N, Kojima T, Fujimoto T, Mitsuhashi S. In vitro properties of the newer quinolones. Prog Drug Res. 1992;38:19-28. PMID: 1609115.
5: Chu DT, Lico IM, Claiborne AK, Plattner JJ, Pernet AG. Structure-activity relationship of quinolone antibacterial agents: the effects of C-2 substitution. Drugs Exp Clin Res. 1990;16(5):215-24. PMID: 1964116.
6: Kotera Y, Inoue Y, Ohashi M, Ito K, Tsukamoto G. Antibacterial activity of a new tetracyclic quinolone, No. 5290, against norfloxacin- and ciprofloxacin- resistant strains of Staphylococcus aureus. Chem Pharm Bull (Tokyo). 1991 Oct;39(10):2644-6. doi: 10.1248/cpb.39.2644. PMID: 1666861.
