Synonym
ANN33840; ANN 33840; ANN-33840; 5-HT2C agonist 58;
IUPAC/Chemical Name
(R)-9-ethyl-7-(trifluoromethyl)-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
InChi Key
AZBGLEQDAYJKBP-NSHDSACASA-N
InChi Code
InChI=1S/C14H15F3N2O/c1-2-8-5-9-11-7-18-3-4-19(11)13(20)12(9)10(6-8)14(15,16)17/h5-6,11,18H,2-4,7H2,1H3/t11-/m0/s1
SMILES Code
O=C1N2[C@](CNCC2)([H])C3=C1C(C(F)(F)F)=CC(CC)=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
284.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP. Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents. J Med Chem. 2015 Feb 26;58(4):1992-2002. doi: 10.1021/jm5019274. Epub 2015 Feb 10. PMID: 25633969; PMCID: PMC4834193.
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3: Zaniewska M, McCreary AC, Wydra K, Filip M. Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal. Neuropharmacology. 2010 Jun;58(7):1140-6. doi: 10.1016/j.neuropharm.2010.02.006. Epub 2010 Feb 11. PMID: 20153341.
4: Sharif NA, Kelly CR, Crider JY, Davis TL. Serotonin-2 (5-HT2) receptor- mediated signal transduction in human ciliary muscle cells: role in ocular hypotension. J Ocul Pharmacol Ther. 2006 Dec;22(6):389-401. doi: 10.1089/jop.2006.22.389. PMID: 17238805.
