Exp6803 | CAS# 114773-44-3 | Angiotensin II receptor antagonist

MedKoo Cat#: 414177 | Name: Exp6803

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Exp6803 is an Angiotensin II receptor antagonist.

Chemical Structure

Exp6803

CAS#114773-44-3

Theoretical Analysis

MedKoo Cat#: 414177

Name: Exp6803

CAS#: 114773-44-3

Chemical Formula: C25H26ClN3O5

Exact Mass: 483.1561

Molecular Weight: 483.95

Elemental Analysis: C, 62.05; H, 5.42; Cl, 7.33; N, 8.68; O, 16.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Exp6803; Exp-6803; Exp 6803

IUPAC/Chemical Name

Methyl 2-n-butyl-1-(4-(2-carboxybenzamido)benzyl)-4-chloroimidazole-5-acetate

InChi Key

VPGBXMVPAQLPJI-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H26ClN3O5/c1-3-4-9-21-28-23(26)20(14-22(30)34-2)29(21)15-16-10-12-17(13-11-16)27-24(31)18-7-5-6-8-19(18)25(32)33/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,27,31)(H,32,33)

SMILES Code

O=C(OC)CC1=C(Cl)N=C(CCCC)N1CC2=CC=C(NC(C3=CC=CC=C3C(O)=O)=O)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 483.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wong PC, Price WA Jr, Chiu AT, Thoolen MJ, Duncia JV, Johnson AL, Timmermans PB. Nonpeptide angiotensin II receptor antagonists. IV. EXP6155 and EXP6803. Hypertension. 1989 May;13(5):489-97. doi: 10.1161/01.hyp.13.5.489. PMID: 2656519. 2: Wong PC, Price WA, Reilly TM, Duncia JV, Timmermans PB. Antihypertensive mechanism of captopril in renal hypertensive rats: studies with a nonpeptide angiotensin II receptor antagonist and an angiotensin II monoclonal antibody. J Pharmacol Exp Ther. 1989 Aug;250(2):515-22. PMID: 2668502. 3: Chiu AT, Duncia JV, McCall DE, Wong PC, Price WA Jr, Thoolen MJ, Carini DJ, Johnson AL, Timmermans PB. Nonpeptide angiotensin II receptor antagonists. III. Structure-function studies. J Pharmacol Exp Ther. 1989 Sep;250(3):867-74. PMID: 2778716. 4: Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL. Nonpeptide angiotensin II receptor antagonists. Am J Hypertens. 1990 Aug;3(8 Pt 1):599-604. doi: 10.1093/ajh/3.8.599. PMID: 2222950. 5: Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL. Angiotensin II receptor antagonists. From discovery to antihypertensive drugs. Hypertension. 1991 Nov;18(5 Suppl):III136-42. doi: 10.1161/01.hyp.18.5_suppl.iii136. PMID: 1937677. 6: Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL. Nonpeptide angiotensin II receptor antagonists: a novel class of antihypertensive agents. Blood Vessels. 1990;27(2-5):295-300. doi: 10.1159/000158821. PMID: 1978694. 7: Chiu AT, Dunscomb JH, McCall DE, Benfield P, Baubonis W, Sauer B. Characterization of angiotensin AT1A receptor isoform by its ligand binding signature. Regul Pept. 1993 Mar 19;44(2):141-7. doi: 10.1016/0167-0115(93)90237-3. PMID: 8469769. 8: Chiu AT, Dunscomb J, Kosierowski J, Burton CR, Santomenna LD, Corjay MH, Benfield P. The ligand binding signatures of the rat AT1A, AT1B and the human AT1 receptors are essentially identical. Biochem Biophys Res Commun. 1993 Dec 15;197(2):440-9. doi: 10.1006/bbrc.1993.2499. PMID: 8267579. 9: Sircar I, Winters RT, Quin J 3rd, Lu GH, Major TC, Panek RL. Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure- activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists. J Med Chem. 1993 Jun 11;36(12):1735-45. doi: 10.1021/jm00064a007. PMID: 8510101.