Cyclosporine A, also known as cyclosporine, is a natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release.
MedKoo Cat#: 300152
Name: Cyclosporine A
CAS#: 59865-13-3
Chemical Formula: C62H111N11O12
Exact Mass: 1201.8414
Molecular Weight: 1202.61
Elemental Analysis: C, 61.92; H, 9.30; N, 12.81; O, 15.96
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 62.0 | 51.60 |
The following data is based on the product molecular weight 1,202.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
