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MedKoo Cat#: 414126 | Name: Etimicin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Etimicin is an Anti-Bacterial and Anti-Infective Agent

Chemical Structure

Etimicin
Etimicin
CAS#59711-96-5

Theoretical Analysis

MedKoo Cat#: 414126

Name: Etimicin

CAS#: 59711-96-5

Chemical Formula: C21H43N5O7

Exact Mass: 477.3162

Molecular Weight: 477.60

Elemental Analysis: C, 52.81; H, 9.08; N, 14.66; O, 23.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Etimicin; Antibiotic 89-07
IUPAC/Chemical Name
(2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4-amino-3-(((2R,3R,6S)-3-amino-6-(aminomethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(ethylamino)-2-hydroxycyclohexyl)oxy)-5-methyl-4-(methylamino)tetrahydro-2H-pyran-3,5-diol
InChi Key
NZGMVSJQULXLHF-RAKCNUBFSA-N
InChi Code
InChI=1S/C21H43N5O7/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20/h10-20,25-29H,4-9,22-24H2,1-3H3/t10-,11+,12-,13+,14-,15+,16+,17-,18+,19+,20+,21-/m0/s1
SMILES Code
CCN[C@@H]1C[C@@H]([C@H]([C@@H]([C@H]1O[C@H]2OC[C@](O)([C@@H]([C@H]2O)NC)C)O)O[C@H]3O[C@@H](CC[C@H]3N)CN)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 477.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shao W, Zhong D, Jiang H, Han Y, Yin Y, Li R, Qian X, Chen D, Jing L. A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos. J Appl Toxicol. 2020 Oct 22. doi: 10.1002/jat.4093. Epub ahead of print. PMID: 33094525. 2: Yao L, Zhang JW, Chen B, Cai MM, Feng D, Wang QZ, Wang XY, Sun JG, Zheng YW, Wang GJ, Zhou F. Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin. Acta Pharmacol Sin. 2020 Jun;41(6):866-878. doi: 10.1038/s41401-019-0342-5. Epub 2020 Jan 14. PMID: 31937930; PMCID: PMC7468263. 3: Wang HX, Zhang LR, Ma XC, Ma TX. Influence of piperacillin on pharmacokinetics of etimicin in healthy volunteers. Acta Pharmacol Sin. 2002 Apr;23(4):376-80. PMID: 11931698. 4: Li ZD, Zhang XL, Yi N, Zhang FC. Elimination of etimicin in rat kidneys and alterations of its cytotoxicity to tubular epithelial cells. Hum Exp Toxicol. 2015 May;34(5):479-86. doi: 10.1177/0960327114550887. Epub 2014 Sep 17. PMID: 25233899. 5: Chaudhary M, Kesava Naidu G, Kumar S, Payasi A. Comparative antibacterial activity of a novel semisynthetic antibiotic: etimicin sulphate and other aminoglycosides. World J Microbiol Biotechnol. 2012 Dec;28(12):3365-71. doi: 10.1007/s11274-012-1148-5. Epub 2012 Sep 15. PMID: 22983905. 6: Yao L, Zhou F, Cai M, Peng Y, Sun J, Chen Q, Jin X, Wang G, Zhang J. Development and validation of a sensitive LC-MS/MS method without derivatization/ion-pairing agents for etimicin quantification in rat plasma, internal ear and kidney. J Pharm Biomed Anal. 2017 Nov 30;146:96-102. doi: 10.1016/j.jpba.2017.08.027. Epub 2017 Aug 24. PMID: 28881316. 7: Zhuang Y, Cao L. Sensitive fluorescence detection of etimicin based on derivatives of formaldehyde and acetylacetone. J Fluoresc. 2013 Jan;23(1):1-5. doi: 10.1007/s10895-012-1121-6. Epub 2012 Aug 24. PMID: 22918626. 8: Cui Y, Ma N, Li X, Lv C, Li M, Li M, Song L, Liu M, Li Q, Bi K. Development of an ultra fast liquid chromatography-tandem mass spectrometry method for simultaneous determination of cefazedone and etimicin in beagle dog plasma: Application to the pharmacokinetic study of the combination of cefazedone and etimicin injections. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Dec 15;973C:97-103. doi: 10.1016/j.jchromb.2014.10.018. Epub 2014 Oct 23. PMID: 25464101. 9: Wu Y, Zhao W, Zhu X, Wang F, Zhang M, Fan X, Yuan Y, Hu C, Deng X, Adams E. Improved liquid chromatography combined with pulsed electrochemical detection for the analysis of etimicin sulfate. J Sep Sci. 2016 Apr;39(8):1471-9. doi: 10.1002/jssc.201501317. PMID: 26924270. 10: Wang H, Zhang Z, Xiong F, Wu L, Li P, Ye W. Isolation and structure characterization of related impurities in etimicin sulfate by LC/ESI-MS(n) and NMR. J Pharm Biomed Anal. 2011 Jul 15;55(5):902-7. doi: 10.1016/j.jpba.2011.03.005. Epub 2011 Mar 8. PMID: 21444173.