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MedKoo Cat#: 464717 | Name: Loxapine-d8
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Loxapine-d8 is intended for use as an internal standard for the quantification of loxapine by GC- or LC-MS. Loxapine is an atypical antipsychotic. It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3 muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to α1A-, α2A-, α2B-, and α2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.

Chemical Structure

Loxapine-d8
Loxapine-d8
CAS#1189455-63-7

Theoretical Analysis

MedKoo Cat#: 464717

Name: Loxapine-d8

CAS#: 1189455-63-7

Chemical Formula: C18H10D8ClN3O

Exact Mass: 335.1641

Molecular Weight: 335.86

Elemental Analysis: C, 64.37; H, 7.80; Cl, 10.55; N, 12.51; O, 4.76

Price and Availability

Size Price Availability Quantity
1mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
Loxapine-d8; Loxapine d8;
IUPAC/Chemical Name
2-chloro-11-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)dibenzo[b,f][1,4]oxazepine
InChi Key
XJGVXQDUIWGIRW-JNJBWJDISA-N
InChi Code
InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3/i8D2,9D2,10D2,11D2
SMILES Code
ClC1=CC2=C(OC3=C(N=C2N4C([2H])(C([2H])(N(C([2H])(C4([2H])[2H])[2H])C)[2H])[2H])C=CC=C3)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 335.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pompili M, Ducci G, Galluzzo A, Rosso G, Palumbo C, De Berardis D. The Management of Psychomotor Agitation Associated with Schizophrenia or Bipolar Disorder: A Brief Review. Int J Environ Res Public Health. 2021 Apr 20;18(8):4368. doi: 10.3390/ijerph18084368. PMID: 33924111; PMCID: PMC8074323. 2: Besag FMC, Vasey MJ, Salim I. Is Adjunct Aripiprazole Effective in Treating Hyperprolactinemia Induced by Psychotropic Medication? A Narrative Review. CNS Drugs. 2021 Apr 20. doi: 10.1007/s40263-021-00812-1. Epub ahead of print. PMID: 33880739. 3: Euwema MS, Swanson TJ. Deadly Single Dose Agents. 2021 Mar 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 28722879. 4: Shrestha S, Agha RS, Khan Z, Shah K, Jain S. Considering Loxapine Instead of Clozapine: A Case Series and Literature Review. Cureus. 2021 Jan 26;13(1):e12919. doi: 10.7759/cureus.12919. PMID: 33654602; PMCID: PMC7906363. 5: Jiang C, Lee SH, Park JH, Lee JS, Park JW, Kim JR, Lee SH, Kim HS, Yoon S. A Low Dose of Aripiprazole Has the Strongest Sensitization Effect Among 19 Repositioned Bipolar Drugs in P-gp-overexpressing Drug-resistant Cancer Cells. Anticancer Res. 2021 Feb;41(2):687-697. doi: 10.21873/anticanres.14820. PMID: 33517273. 6: Pacchiarotti I, Anmella G, Colomer L, Vieta E. How to treat mania. Acta Psychiatr Scand. 2020 Sep;142(3):173-192. doi: 10.1111/acps.13209. Epub 2020 Aug 3. PMID: 33460070. 7: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Loxapine. 2021 Jan 18. PMID: 30000069. 8: Cabrera-Mendoza B, Martínez-Magaña JJ, Monroy-Jaramillo N, Genis-Mendoza AD, Fresno C, Fries GR, Walss-Bass C, López Armenta M, García-Dolores F, Díaz-Otañez CE, Flores G, Vázquez-Roque RA, Nicolini H. Candidate pharmacological treatments for substance use disorder and suicide identified by gene co-expression network- based drug repositioning. Am J Med Genet B Neuropsychiatr Genet. 2021 Apr;186(3):193-206. doi: 10.1002/ajmg.b.32830. Epub 2021 Jan 6. PMID: 33403748. 9: Citrome L. Agitation in schizophrenia: origins and evidence-based treatment. Curr Opin Psychiatry. 2021 May 1;34(3):216-221. doi: 10.1097/YCO.0000000000000685. PMID: 33395103. 10: Rosso G, Teobaldi E, Maina G. Inhaled Loxapine as an Option for Psychomotor Agitation in Complex Patients. J Clin Psychopharmacol. 2020 Nov/Dec;40(6):645-647. doi: 10.1097/JCP.0000000000001290. PMID: 33065716. 11: Trawiński J, Kozioł E, Skibiński R. Influence of the UV-Vis irradiation on the acute toxicity to zebrafish and mutagenicity of the selected psychotropic drugs. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2020;55(14):1624-1637. doi: 10.1080/10934529.2020.1829890. Epub 2020 Oct 12. PMID: 33043805. 12: Yip L, Aeng E, Elbe D. Management of Acute Agitation and Aggression in Children and Adolescents with Pro Re Nata Oral Immediate Release Antipsychotics in the Pediatric Emergency Department. J Child Adolesc Psychopharmacol. 2020 Nov;30(9):534-541. doi: 10.1089/cap.2019.0171. Epub 2020 Oct 9. PMID: 33035069. 13: Macoin E, Kintz P, Gressel A, Leyendecker P, Raul JS, Walch A. The Importance of Autopsy in a Case of Digestive Perforation Undetected by Postmortem Computed Tomography. Am J Forensic Med Pathol. 2021 Jun 1;42(2):201-204. doi: 10.1097/PAF.0000000000000617. PMID: 32956075. 14: Saito K, Hagiwara N, Sakamoto M, Wakana D, Ito R, Hosoe T. Elucidation of Degradation Behavior of Tricyclic Antidepressant Amoxapine in Artificial Gastric Juice. Chem Pharm Bull (Tokyo). 2020;68(9):848-854. doi: 10.1248/cpb.c20-00313. PMID: 32879225. 15: Kasap M, Dwyer DS. Clozapine, nimodipine and endosulfan differentially suppress behavioral defects caused by gain-of-function mutations in a two-pore domain K+ channel (UNC-58). Neurosci Res. 2020 Jul 15:S0168-0102(20)30406-5. doi: 10.1016/j.neures.2020.07.006. Epub ahead of print. PMID: 32681854. 16: Orsolini L, De Berardis D, Volpe U. Up-to-date expert opinion on the safety of recently developed antipsychotics. Expert Opin Drug Saf. 2020 Aug;19(8):981-998. doi: 10.1080/14740338.2020.1795126. Epub 2020 Jul 21. PMID: 32657173. 17: Sid-Otmane L, Huot P, Panisset M. Effect of Antidepressants on Psychotic Symptoms in Parkinson Disease: A Review of Case Reports and Case Series. Clin Neuropharmacol. 2020 May/Jun;43(3):61-65. doi: 10.1097/WNF.0000000000000384. PMID: 32217864. 18: Andersson JA, Peniche AG, Galindo CL, Boonma P, Sha J, Luna RA, Savidge TC, Chopra AK, Dann SM. New Host-Directed Therapeutics for the Treatment of Clostridioides difficile Infection. mBio. 2020 Mar 10;11(2):e00053-20. doi: 10.1128/mBio.00053-20. PMID: 32156806; PMCID: PMC7064747. 19: Chrétien B, Lelong-Boulouard V, Chantepie S, Sassier M, Bertho M, Brazo P, Humbert X, Alexandre J, Fedrizzi S, Dolladille C. Haematologic malignancies associated with clozapine v. all other antipsychotic agents: a pharmacovigilance study in VigiBase®. Psychol Med. 2020 Feb 10:1-8. doi: 10.1017/S0033291720000161. Epub ahead of print. PMID: 32036793. 20: Nolen A, Dai T. Diphenhydramine Use Disorder and Complicated Withdrawal in a Palliative Care Patient. J Palliat Med. 2020 Sep;23(9):1279-1282. doi: 10.1089/jpm.2019.0308. Epub 2019 Dec 5. PMID: 31808723.