Synonym
Etimizol; BRN0525707; BRN-0525707; BRN 0525707
IUPAC/Chemical Name
1H-Imidazole-4,5-dicarboxamide, 1-ethyl-N,N'-dimethyl-
InChi Key
RYRFAMRQBZNEPX-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H14N4O2/c1-4-13-5-12-6(8(14)10-2)7(13)9(15)11-3/h5H,4H2,1-3H3,(H,10,14)(H,11,15)
SMILES Code
O=C(C1=C(C(NC)=O)N(CC)C=N1)NC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
210.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Vislobokov AI, Mnukhina RS. Elektrofiziologicheskie parametry neĭronov molliuska pri deĭstvii étimizola [Elektrophysiological parameters of mollusk neurons under the influence of etimizol]. Fiziol Zh SSSR Im I M Sechenova. 1975 Jun;61(6):917-24. Russian. PMID: 1132537.
2: Trnovec T, Faberová V, Piotrovskiĭ LB, Durisová M, Gabauer I. Absorbtsiia étimizola iz tonkoĭ kishki sobak: zavisimost' ot dozy [Etimizol absorption from the small intestine in dogs: the dependence on dosage]. Biull Eksp Biol Med. 1986 Dec;102(12):729-30. Russian. PMID: 3801627.
3: Kompantseva EV. Reaktsii identifikatsii étimizola [Etimizol identification reactions]. Farmatsiia. 1974 Sep-Oct;23(5):84. Russian. PMID: 4464158.
4: Reikhardt BA, Shabanov PD. Vliianie strukturnykh analogov étimizola na proteinkinazu SK2, fosforilirovanie belkov i transkriptsiiu khromatina neĭronov kory i gippokampa mozga krys [Effect of etimizole structural analogues on protein kinase CK2, protein phosphorylation and transcription of chromatin in rat brain cortex and hippocampus]. Biomed Khim. 2020 Feb;66(2):130-137. Russian. doi: 10.18097/PBMC20206602130. PMID: 32420893.
5: Borisova GIu. Vliianie étimizola na instrumental'noe obuchenie krys [Effect of etimizol on instrumental learning in rats]. Biull Eksp Biol Med. 1985 Jun;99(6):705-6. Russian. PMID: 4016262.
6: Neĭko IeM, Mytnyk ZM, Holovach IIu. Dyferentsiĭovani pidkhody do likuvannia khronichnykh dyfuznykh urazhen' pechinky iz zastosuvanniam ornitsetylu, laktulozy, etymizolu ta korynfaru [Different therapeutic approaches for chronic diffuse liver lesions using ornicetil, lactulose, etimizol and corinfar]. Lik Sprava. 2002;(2):64-8. Ukrainian. PMID: 12073265.
7: Migas EA, Zavodskaia IS, Kachalov IuP, Chernysheva ON. Ispol'zovanie biologicheskikh metodov dlia analiza purinergicheskoĭ aktivnosti étimizola [Use of biological methods in the analysis of the purinergic activity of etimizol]. Biull Eksp Biol Med. 1988 Oct;106(10):462-4. Russian. PMID: 3191239.
8: Belikov VG, Tsybulina MG, Klochkov SV, Vergeĭchik TKh. Spektrofotometricheskoe opredelenie metronidazola i étimizola pri sovmestnom prisutstvii v moche [The spectrophotometric determination of metronidazole and etimizol when jointly present in the urine]. Sud Med Ekspert. 1995 Oct- Dec;38(4):27-9. Russian. PMID: 8848799.
9: Borodkin IuS, Iaichnikov IK. Analiz gipotermicheskogo deĭstviia étimizola [Analysis of the hypothermic action of etimizol]. Farmakol Toksikol. 1988 Jul- Aug;51(4):34-5. Russian. PMID: 3191969.
10: Zaĭtsev IuV, Shabanov PD, Bogoslovskaia SI, Krauz VA, Fisher KhD. Znachenie antigipoksicheskikh svoĭstv étimizola v ego nootropnom deĭstvii [The significance of the antihypoxic properties of etimizol in its nootropic action]. Farmakol Toksikol. 1988 Sep-Oct;51(5):27-30. Russian. PMID: 3145213.
