AUN-25081 is an active metabolite of L-leucine. It is produced from leucine via an α-ketoisocaproic acid intermediate by α-ketoisocaproate oxidase in human liver homogenates. AUN-25081 (50 µM) reduces increases in 20S proteasome activity and NF-κB nuclear accumulation induced by proteolysis-inducing factor (PIF) in C2C12 myotubes. It inhibits protein degradation and stimulates protein synthesis in the gastrocnemius muscle of cachectic mice bearing MAC16 tumors when administered at doses of 0.25 and 2.5 g/kg. Urinary levels of AUN-25081 acid are increased in patients with type II diabetes. Formulations containing AUN-25081 acid have been used as dietary supplements. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).
MedKoo Cat#: 464715
Name: AUN-25081
CAS#: 625-08-1
Chemical Formula: C5H10O3
Exact Mass: 118.0630
Molecular Weight: 118.13
Elemental Analysis: C, 50.84; H, 8.53; O, 40.63
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 10.0 | 84.65 | |
| DMSO | 10.0 | 84.65 | |
| Ethanol | 10.0 | 84.65 | |
| PBS (pH 7.2) | 10.0 | 84.65 |
The following data is based on the product molecular weight 118.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
