Synonym
Sulfaethidole; VK55; VK-55; VK 55
IUPAC/Chemical Name
Benzenesulfonamide, 4-amino-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-
InChi Key
SVYBEBLNQGDRHF-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H12N4O2S2/c1-2-9-12-13-10(17-9)14-18(15,16)8-5-3-7(11)4-6-8/h3-6H,2,11H2,1H3,(H,13,14)
SMILES Code
O=S(C1=CC=C(N)C=C1)(NC2=NN=C(CC)S2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
284.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: SULFAETHIDOLE. J Am Med Assoc. 1958 Aug 16;167(16):1937. PMID: 13563204.
2: DeSante KA, Dittert LW, Stavchansky S, Doluisio JT. Influence of sulfaethidole on the human pharmacokinetics of dicloxacillin. J Clin Pharmacol. 1980 Aug-Sep;20(8-9):534-42. doi: 10.1002/j.1552-4604.1980.tb02547.x. PMID: 6893599.
3: Crouthamel WG, Diamond L, Dittert LW, Doluisio JT. Drug absorption VII: influence of mesenteric blood flow on intestinal drug absorption in dogs. J Pharm Sci. 1975 Apr;64(4):664-71. doi: 10.1002/jps.2600640420. PMID: 1173597.
4: Julkunen RJ. pH-dependency in diffusion of some weakly acidic drugs, warfarin, sulfaethidole, and barbital, into organic phases. Med Biol. 1977 Feb;55(1):41-7. PMID: 15170.
5: Janssen LH, Nelen TH. Influence of hydrogen and chloride ions on the interaction between sulfaethidole and bovine serum albumin studied by microcalorimetric and acid-base titrimetric methods. J Biol Chem. 1979 Jun 25;254(12):5300-3. PMID: 36383.
6: Kekki M, Julkunen RJ, Pohjanpalo H. Pharmacokinetics of sulfaethidole in the rat: nonlinear multicompartment solution. J Pharmacokinet Biopharm. 1982 Feb;10(1):27-51. doi: 10.1007/BF01059182. PMID: 6896071.
7: KOSTENBAUDER HB, PORTNOFF JB, SWINTOSKY JV. Control of urine pH and its effect on sulfaethidole excretion in humans. J Pharm Sci. 1962 Nov;51:1084-9. doi: 10.1002/jps.2600511117. PMID: 14035027.
8: Perrin JH, Otagiri M, van Wilgenburg-Beernink MT. The effect of fatty acids and sodium doecyl sulfate on the induced optical activity of sulfaethidole - BSA complexes. Biochem Pharmacol. 1976 Oct 15;25(20):2329-30. doi: 10.1016/0006-2952(76)90018-6. PMID: 990101.
9: Perrin JH, Nelson DA. Displacement of sulfaethidole from bovine serum albumin by some alkyldimethylbenzylammonium chlorides. Biochem Pharmacol. 1974 Nov 15;23(22):3139-45. doi: 10.1016/0006-2952(74)90599-1. PMID: 4479939.
10: Perrin JH, Nelson DA. Reduced binding of sulfaethidole to bovine serum albumin in presence of benzalkonium chloride. J Pharm Sci. 1975 Feb;64(2):361-2. doi: 10.1002/jps.2600640246. PMID: 1173246.
