Macropa-NH2 | CAS#2146095-13-6

MedKoo Cat#: 555995 | Name: Macropa-NH2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Macropa-NH2 is the precursor of making Macropa-NCS, which can be an important agent to make Antibody drug conjute (ADC). Macropa is a mctrocyclic ligand showed strong affinity to barium-131, and other radiolabeling agents. Macropa-NH2 is useful to make radio-isotopic based image agent.

Chemical Structure

Macropa-NH2

CAS#2146095-13-6

Theoretical Analysis

MedKoo Cat#: 555995

Name: Macropa-NH2

CAS#: 2146095-13-6

Chemical Formula: C26H37N5O8

Exact Mass: 547.2642

Molecular Weight: 547.61

Elemental Analysis: C, 57.03; H, 6.81; N, 12.79; O, 23.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Macropa-NH2

IUPAC/Chemical Name

4-amino-6-((16-((6-carboxypyridin-2-yl)methyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)methyl)picolinic acid

InChi Key

WABTUXPZUNQNCC-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H37N5O8/c27-20-16-22(29-24(17-20)26(34)35)19-31-6-10-38-14-12-36-8-4-30(5-9-37-13-15-39-11-7-31)18-21-2-1-3-23(28-21)25(32)33/h1-3,16-17H,4-15,18-19H2,(H2,27,29)(H,32,33)(H,34,35)

SMILES Code

O=C(O)C1=NC(CN2CCOCCOCCN(CC3=NC(C(O)=O)=CC=C3)CCOCCOCC2)=CC(N)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 547.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kovács A. Theoretical Study of Actinide Complexes with Macropa. ACS Omega. 2020 Oct 6;5(41):26431-26440. doi: 10.1021/acsomega.0c02873. PMID: 33110971; PMCID: PMC7581080. 2: Thiele NA, Brown V, Kelly JM, Amor-Coarasa A, Jermilova U, MacMillan SN, Nikolopoulou A, Ponnala S, Ramogida CF, Robertson AKH, Rodríguez-Rodríguez C, Schaffer P, Williams C Jr, Babich JW, Radchenko V, Wilson JJ. An Eighteen- Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14712-14717. doi: 10.1002/anie.201709532. Epub 2017 Oct 16. PMID: 28963750. 3: Thiele NA, MacMillan SN, Wilson JJ. Rapid Dissolution of BaSO4 by Macropa, an 18-Membered Macrocycle with High Affinity for Ba2. J Am Chem Soc. 2018 Dec 12;140(49):17071-17078. doi: 10.1021/jacs.8b08704. Epub 2018 Nov 28. PMID: 30485079; PMCID: PMC6560633. 4: Bell MM, Gutsche NT, King AP, Baidoo KE, Kelada OJ, Choyke PL, Escorcia FE. Glypican-3-Targeted Alpha Particle Therapy for Hepatocellular Carcinoma. Molecules. 2020 Dec 22;26(1):4. doi: 10.3390/molecules26010004. PMID: 33374953; PMCID: PMC7792624. 5: Thiele NA, Woods JJ, Wilson JJ. Implementing f-Block Metal Ions in Medicine: Tuning the Size Selectivity of Expanded Macrocycles. Inorg Chem. 2019 Aug 19;58(16):10483-10500. doi: 10.1021/acs.inorgchem.9b01277. Epub 2019 Jun 27. PMID: 31246017. 6: Li L, Rousseau J, Jaraquemada-Peláez MG, Wang X, Robertson A, Radchenko V, Schaffer P, Lin KS, Bénard F, Orvig C. 225Ac-H4py4pa for Targeted Alpha Therapy. Bioconjug Chem. 2020 Apr 9. doi: 10.1021/acs.bioconjchem.0c00171. Epub ahead of print. PMID: 32216377. 7: Thiele NA, Fiszbein DJ, Woods JJ, Wilson JJ. Tuning the Separation of Light Lanthanides Using a Reverse-Size Selective Aqueous Complexant. Inorg Chem. 2020 Nov 16;59(22):16522-16530. doi: 10.1021/acs.inorgchem.0c02413. Epub 2020 Oct 24. PMID: 33103417. 8: Aluicio-Sarduy E, Thiele NA, Martin KE, Vaughn BA, Devaraj J, Olson AP, Barnhart TE, Wilson JJ, Boros E, Engle JW. Establishing Radiolanthanum Chemistry for Targeted Nuclear Medicine Applications. Chemistry. 2020 Jan 27;26(6):1238-1242. doi: 10.1002/chem.201905202. Epub 2020 Jan 9. PMID: 31743504; PMCID: PMC7261199. 9: Reissig F, Bauer D, Ullrich M, Kreller M, Pietzsch J, Mamat C, Kopka K, Pietzsch HJ, Walther M. Recent Insights in Barium-131 as a Diagnostic Match for Radium-223: Cyclotron Production, Separation, Radiolabeling, and Imaging. Pharmaceuticals (Basel). 2020 Sep 25;13(10):272. doi: 10.3390/ph13100272. PMID: 32992909; PMCID: PMC7599757. 10: Yang H, Zhang C, Yuan Z, Rodriguez-Rodriguez C, Robertson A, Radchenko V, Perron R, Gendron D, Causey P, Gao F, Bénard F, Schaffer P. Synthesis and Evaluation of a Macrocyclic Actinium-225 Chelator, Quality Control and In Vivo Evaluation of 225 Ac-crown-αMSH Peptide. Chemistry. 2020 Sep 4;26(50):11435-11440. doi: 10.1002/chem.202002999. Epub 2020 Aug 28. PMID: 32588455. 11: Nelson BJB, Wilson J, Andersson JD, Wuest F. High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine. Sci Rep. 2020 Dec 17;10(1):22203. doi: 10.1038/s41598-020-79198-x. PMID: 33335271; PMCID: PMC7747723. 12: Solomon VR, Barreto K, Bernhard W, Alizadeh E, Causey P, Perron R, Gendron D, Alam MK, Carr A, Geyer CR, Fonge H. Nimotuzumab Site-Specifically Labeled with 89Zr and 225Ac Using SpyTag/SpyCatcher for PET Imaging and Alpha Particle Radioimmunotherapy of Epidermal Growth Factor Receptor Positive Cancers. Cancers (Basel). 2020 Nov 20;12(11):3449. doi: 10.3390/cancers12113449. PMID: 33233524; PMCID: PMC7699480. 13: Kelly JM, Amor-Coarasa A, Ponnala S, Nikolopoulou A, Williams C Jr, Thiele NA, Schlyer D, Wilson JJ, DiMagno SG, Babich JW. A Single Dose of 225Ac-RPS-074 Induces a Complete Tumor Response in an LNCaP Xenograft Model. J Nucl Med. 2019 May;60(5):649-655. doi: 10.2967/jnumed.118.219592. Epub 2018 Nov 9. PMID: 30413660. 14: Zeidler W. New and additional records of hyperiidean amphipods of the infraorder Physosomata (Crustacea: Amphipoda: Hyperiidea) from the Antarctic Zone of the Southern Ocean. Zootaxa. 2019 Apr 3;4576(3):zootaxa.4576.3.5. doi: 10.11646/zootaxa.4576.3.5. PMID: 31715750. 15: Thiele NA, Wilson JJ. Actinium-225 for Targeted α Therapy: Coordination Chemistry and Current Chelation Approaches. Cancer Biother Radiopharm. 2018 Oct;33(8):336-348. doi: 10.1089/cbr.2018.2494. Epub 2018 Jun 11. PMID: 29889562; PMCID: PMC6207149.