5-Fluoro-thalidomide is a useful precursor for synthesis of PROTAC degrader. 5-Fluoro-thalidomide is a Thalidomide-based cereblon ligand that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
MedKoo Cat#: 408149
Name: 5-Fluoro-thalidomide
CAS#: 835616-61-0
Chemical Formula: C13H9FN2O4
Exact Mass: 276.0546
Molecular Weight: 276.22
Elemental Analysis: C, 56.53; H, 3.28; F, 6.88; N, 10.14; O, 23.17
The following data is based on the product molecular weight 276.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
