Naamidine A | CAS#110189-06-5 | EGFR-dependent Cellular Proliferation Inhibitor

MedKoo Cat#: 110226 | Name: Naamidine A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Naamidine A is a marine alkaloid with a selective ability to inhibit epidermal growth factor receptor (EGFR)-dependent cellular proliferation.

Chemical Structure

Naamidine A

CAS#110189-06-5

Theoretical Analysis

MedKoo Cat#: 110226

Name: Naamidine A

CAS#: 110189-06-5

Chemical Formula: C23H23N5O4

Exact Mass: 433.1750

Molecular Weight: 433.47

Elemental Analysis: C, 63.73; H, 5.35; N, 16.16; O, 14.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Naamidine A

IUPAC/Chemical Name

4-((5-(4-Hydroxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)amino)-1-methyl-1H-imidazole-2,5-dione

InChi Key

REQFUGYVPAQCTH-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H23N5O4/c1-27-19(13-15-4-8-16(29)9-5-15)18(12-14-6-10-17(32-3)11-7-14)24-22(27)25-20-21(30)28(2)23(31)26-20/h4-11,29H,12-13H2,1-3H3,(H,24,25,26,31)

SMILES Code

O=C1N=C(NC2=NC(CC3=CC=C(OC)C=C3)=C(CC4=CC=C(O)C=C4)N2C)C(N1C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 433.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Gibbons JB, Salvant JM, Vaden RM, Kwon KH, Welm BE, Looper RE. Synthesis of Naamidine A and Selective Access to N(2)-Acyl-2-aminoimidazole Analogues. J Org Chem. 2015 Oct 16;80(20):10076-85. doi: 10.1021/acs.joc.5b01703. Epub 2015 Sep 24. PMID: 26360634; PMCID: PMC5117189.