IT-066 HCl | CAS# 126463-66-9 | Biochemical

MedKoo Cat#: 576793 | Name: IT-066 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IT-066 HCl is a histamine H2 receptor antagonist.

Chemical Structure

IT-066 HCl

CAS#126463-66-9

Theoretical Analysis

MedKoo Cat#: 576793

Name: IT-066 HCl

CAS#: 126463-66-9

Chemical Formula: C19H25ClN4O3

Exact Mass: 392.1615

Molecular Weight: 392.88

Elemental Analysis: C, 58.09; H, 6.41; Cl, 9.02; N, 14.26; O, 12.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

IT-066 HCl; IT 066 HCl; IT066 HCl; IT-066 hydrochloride; Pibutidine hydrochloride; Pibutidine HCl

IUPAC/Chemical Name

3-Cyclobutene-1,2-dione, 3-amino-4-((4-((4-(1-piperidinylmethyl)-2-pyridinyl)oxy)-2-butenyl)amino)-, monohydrochloride, (Z)-

InChi Key

ODBOENMSSFCACZ-PVOKDAACSA-N

InChi Code

InChI=1S/C19H24N4O3.ClH/c20-16-17(19(25)18(16)24)22-7-2-5-11-26-15-12-14(6-8-21-15)13-23-9-3-1-4-10-23;/h2,5-6,8,12,22H,1,3-4,7,9-11,13,20H2;1H/b5-2-;

SMILES Code

Cl.NC1=C(NC\C=C/COc2cc(CN3CCCCC3)ccn2)C(=O)C1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 392.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Kaku S, Isobe Y, Kiuchi Y, Tanaka M, Muramatsu M, Higuchi S. Interaction of the new histamine H2-receptor antagonist pibutidine hydrochloride with canine cloned H2-receptor expressed cells. Arzneimittelforschung. 1999 Jan;49(1):67-71. doi: 10.1055/s-0031-1300362. PMID: 10028383. 2. Naito Y, Yoshikawa T, Matsuyama K, Yagi N, Arai M, Nakamura Y, Kaneko T, Yoshida N, Kondo M. Effect of a novel histamine H2 receptor antagonist, IT-066, on acute gastric injury induced by ischemia-reperfusion in rats, and its antioxidative properties. Eur J Pharmacol. 1995 Dec 27;294(1):47-54. doi: 10.1016/0014-2999(95)00512-9. PMID: 8788415.