IUPAC/Chemical Name
1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-methylpropyl)-
InChi Key
WHUWQSQEVISUMC-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H16N4O2/c1-7(2)5-15-6-12-9-8(15)10(16)14(4)11(17)13(9)3/h6-7H,5H2,1-4H3
SMILES Code
CC(C)Cn1cnc2N(C)C(=O)N(C)C(=O)c12
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
236.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Manzini S, Perretti F, Abelli L, Evangelista S, Seeds EA, Page CP. Isbufylline, a new xanthine derivative, inhibits airway hyperresponsiveness and airway inflammation in guinea pigs. Eur J Pharmacol. 1993 Nov 16;249(3):251-7. doi: 10.1016/0014-2999(93)90519-n. PMID: 7507057.
2. Manzini S, Meini S, Giachetti A, Beani L, Borea PA, Antonelli T, Ballati L, Bacciarelli C. Pharmacodynamic profile of isbufylline, a new antibronchospastic xanthine devoid of central excitatory actions. Arzneimittelforschung. 1990 Nov;40(11):1205-13. PMID: 1707621.
3. Meini S, Ballati L, Evangelista S, Manzini S. Isbufylline, a xanthine derivative, inhibits bronchoconstrictor responses produced by stimulation of capsaicin-sensitive sensory nerves in guinea-pig: 'In vitro' and 'in vivo' evidence. Pulm Pharmacol. 1993 Dec;6(4):279-86. doi: 10.1006/pulp.1993.1037. PMID: 7511949.
4. Agostini O, Bonacchi G, Coppini G, Toja E, Triolo A, Manzini S, Pieraccini G, Moneti G. Metabolism of isbufylline in humans. Isolation, identification, and synthesis of plasma and urine metabolites. Drug Metab Dispos. 1994 Mar-Apr;22(2):259-68. PMID: 7516853.
