Synonym
TML; Nε,Nε,Nε-Trimethyllysine chloride, N6-Trimethyllysine; Nε-Trimethyllysine;
IUPAC/Chemical Name
(S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium chloride
InChi Key
ZKIJKCHCMFGMCM-QRPNPIFTSA-N
InChi Code
InChI=1S/C9H20N2O2.ClH/c1-11(2,3)7-5-4-6-8(10)9(12)13;/h8H,4-7,10H2,1-3H3;1H/t8-;/m0./s1
SMILES Code
C[N+](C)(CCCC[C@@H](C(O)=O)N)C.[Cl-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| PBS (pH 7.2) |
1.0 |
4.45 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
224.73
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Servillo L, D'Onofrio N, Neglia G, Casale R, Cautela D, Marrelli M, Limone A, Campanile G, Balestrieri ML. Carnitine Precursors and Short-Chain Acylcarnitines in Water Buffalo Milk. J Agric Food Chem. 2018 Aug 1;66(30):8142-8149. doi: 10.1021/acs.jafc.8b02963. Epub 2018 Jul 24. PMID: 30011990.
2: Liebeke M, Bruford MW, Donnelly RK, Ebbels TM, Hao J, Kille P, Lahive E, Madison RM, Morgan AJ, Pinto-Juma GA, Spurgeon DJ, Svendsen C, Bundy JG. Identifying biochemical phenotypic differences between cryptic species. Biol Lett. 2014 Sep;10(9):20140615. doi: 10.1098/rsbl.2014.0615. PMID: 25252836; PMCID: PMC4190966.
3: Liang Z, Wong RP, Li LH, Jiang H, Xiao H, Li G. Development of pan-specific antibody against trimethyllysine for protein research. Proteome Sci. 2008 Jan 22;6:2. doi: 10.1186/1477-5956-6-2. PMID: 18208619; PMCID: PMC2267453.
4: Tomita T, Nakamura K. Isolation and identification of NG-monomethyl-,NG,NG- dimethylarginine and Nepsilon-trimethyllysine from human placenta[1]. Hoppe Seylers Z Physiol Chem. 1977 Mar;358(3):413-6. PMID: 852825.
5: Morse RK, Vergnes JP, Malloy J, McManus IR. Sites of biological methylation of proteins in cultured chick muscle cells. Biochemistry. 1975 Sep 23;14(19):4316-25. doi: 10.1021/bi00690a028. PMID: 1101948.
