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MedKoo Cat#: 414020 | Name: Enisamium Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Enisamium Free Base exhibits antiviral activity against influenza viruses in vitro.

Chemical Structure

Enisamium Free Base
Enisamium Free Base
CAS#116533-18-7 (free base)

Theoretical Analysis

MedKoo Cat#: 414020

Name: Enisamium Free Base

CAS#: 116533-18-7 (free base)

Chemical Formula: C14H15N2O+

Exact Mass: 227.1179

Molecular Weight: 227.29

Elemental Analysis: C, 73.98; H, 6.65; N, 12.33; O, 7.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Enisamium ion; Enisamium Free Base; Enisamium cation
IUPAC/Chemical Name
4-(Benzylcarbamoyl)-1-methylpyridin-1-ium
InChi Key
QOEJDHLJOKRPJG-UHFFFAOYSA-O
InChi Code
InChI=1S/C14H14N2O/c1-16-9-7-13(8-10-16)14(17)15-11-12-5-3-2-4-6-12/h2-10H,11H2,1H3/p+1
SMILES Code
C[N+]1=CC=C(C(NCC2=CC=CC=C2)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 227.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Walker AP, Fan H, Keown JR, Margitich V, Grimes JM, Fodor E, Te Velthuis AJW. Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases. bioRxiv [Preprint]. 2020 Jan 6:2020.04.21.053017. doi: 10.1101/2020.04.21.053017. PMID: 32511388; PMCID: PMC7263517. 2: Haltner-Ukomadu E, Gureyeva S, Burmaka O, Goy A, Mueller L, Kostyuk G, Margitich V. In Vitro Bioavailability Study of an Antiviral Compound Enisamium Iodide. Sci Pharm. 2018 Jan 11;86(1):3. doi: 10.3390/scipharm86010003. PMID: 29324660; PMCID: PMC5874533. 3: Boltz D, Peng X, Muzzio M, Dash P, Thomas PG, Margitich V. Activity of enisamium, an isonicotinic acid derivative, against influenza viruses in differentiated normal human bronchial epithelial cells. Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618811416. doi: 10.1177/2040206618811416. PMID: 30466301; PMCID: PMC6961345. 4: Zarubaev VV, Slita AV, Sinegubova EO, Muryleva AA, Lavrentieva IN. [Anti- viral activity of enisamium iodide against viruses of influenza and ARVI's on different cell lines]. Ter Arkh. 2020 Dec 26;92(11):45-50. Russian. doi: 10.26442/00403660.2020.11.000872. PMID: 33720603. 5: Holubovska O, Bojkova D, Elli S, Bechtel M, Boltz D, Muzzio M, Peng X, Sala F, Cosentino C, Mironenko A, Milde J, Lebed Y, Stammer H, Goy A, Guerrini M, Mueller L, Cinatl J, Margitich V, Te Velthuis AJW. Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial. medRxiv [Preprint]. 2021 Jan 12:2021.01.05.21249237. doi: 10.1101/2021.01.05.21249237. PMID: 33469600; PMCID: PMC7814846. 6: Cocking D, Cinatl J, Boltz DA, Peng X, Johnson W, Muzzio M, Syarkevych O, Kostyuk G, Goy A, Mueller L, Margitich VI. Antiviral effect of a derivative of isonicotinic acid enisamium iodide (FAV00A) against influenza virus. Acta Virol. 2018;62(2):191-195. doi: 10.4149/av_2018_211. PMID: 29895160. 7: Lioznov DA, Karnaukhova EJ, Zubkova TG, Shakhlanskaya EV. [Evaluation of the effectiveness of ARVI treatment regimen including etiotropic (enisamium iodide) and symptomatic treatment]. Ter Arkh. 2020 Apr 27;92(3):50-55. Russian. doi: 10.26442/00403660.2020.03.000572. PMID: 32598793. 8: Te Velthuis AJW, Zubkova TG, Shaw M, Mehle A, Boltz D, Gmeinwieser N, Stammer H, Milde J, Müller L, Margitich V. Enisamium Reduces Influenza Virus Shedding and Improves Patient Recovery by Inhibiting Viral RNA Polymerase Activity. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02605-20. doi: 10.1128/AAC.02605-20. PMID: 33558285; PMCID: PMC8097484. 9: Pshenichnaya NY, Bulgakova VA, Volchkova EV, Kareva EN, Selkova EP, Gorodin VN. [Review of current and future directions of antiviral therapy of influenza and acute respiratory viral infections in Russia]. Ter Arkh. 2019 Nov 15;91(11):105-109. Russian. doi: 10.26442/00403660.2019.11.000454. PMID: 32598620. 10: Zupanets I, Zhulai T, Shebeko S, Otrishko I, Hladkykh D. Histomorphological Study of a New Nasal Spray with Anti-inflammatory Properties Efficacy in Rabbits with Rhinosinusitis. Med Arch. 2020 Feb;74(1):8-13. doi: 10.5455/medarh.2020.74.8-13. PMID: 32317827; PMCID: PMC7164735.

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