Iroxanadine hydrobromide | CAS# 276690-62-1 | Biochemical

MedKoo Cat#: 576771 | Name: Iroxanadine hydrobromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Iroxanadine hydrobromide is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.

Chemical Structure

Iroxanadine hydrobromide

CAS#276690-62-1

Theoretical Analysis

MedKoo Cat#: 576771

Name: Iroxanadine hydrobromide

CAS#: 276690-62-1

Chemical Formula: C14H21BrN4O

Exact Mass: 340.0899

Molecular Weight: 341.25

Elemental Analysis: C, 49.28; H, 6.20; Br, 23.41; N, 16.42; O, 4.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Iroxanadine hydrobromide; Iroxanadine HBr

IUPAC/Chemical Name

2H-1,2,4-Oxadiazine, 5,6-dihydro-5-(1-piperidinylmethyl)-3-(3-pyridinyl)-, monohydrobromide, (-)-

InChi Key

JHDYJJZPWVTMRM-UHFFFAOYSA-N

InChi Code

1S/C14H20N4O.BrH/c1-2-7-18(8-3-1)10-13-11-19-17-14(16-13)12-5-4-6-15-9-12;/h4-6,9,13H,1-3,7-8,10-11H2,(H,16,17);1H

SMILES Code

Br.C(C1CONC(=N1)c2cccnc2)N3CCCCC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 341.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Denes L, Bori Z, Csonka E, Entz L, Nagy Z. Reverse regulation of endothelial cells and myointimal hyperplasia on cell proliferation by a heatshock protein-coinducer after hypoxia. Stroke. 2008 Mar;39(3):1022-4. doi: 10.1161/STROKEAHA.107.495754. PubMed PMID: 18239173. 2: Kabakov AE, Budagova KR, Malyutina YV, Latchman DS, Csermely P. Pharmacological attenuation of apoptosis in reoxygenated endothelial cells. Cell Mol Life Sci. 2004 Dec;61(24):3076-86. PubMed PMID: 15583868. 3: Denes L, Entz L, Jancsik V. Restenosis and therapy. Int J Vasc Med. 2012;2012:406236. doi: 10.1155/2012/406236. PubMed PMID: 22489270; PubMed Central PMCID: PMC3303576. 4: Dénes L, Jednákovits A, Hargitai J, Pénzes Z, Balla A, Tálosi L, Krajcsi P, Csermely P. Pharmacologically activated migration of aortic endothelial cells is mediated through p38 SAPK. Br J Pharmacol. 2002 Jun;136(4):597-603. PubMed PMID: 12055138; PubMed Central PMCID: PMC1573374.