MedKoo Cat#: 576770 | Name: Iroxanadine sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Iroxanadine sulfate is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.

Chemical Structure

Iroxanadine sulfate
Iroxanadine sulfate
CAS#276690-61-0

Theoretical Analysis

MedKoo Cat#: 576770

Name: Iroxanadine sulfate

CAS#: 276690-61-0

Chemical Formula: C14H22N4O5S

Exact Mass: 358.1311

Molecular Weight: 358.41

Elemental Analysis: C, 46.92; H, 6.19; N, 15.63; O, 22.32; S, 8.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Iroxanadine sulfate
IUPAC/Chemical Name
2H-1,2,4-Oxadiazine, 5,6-dihydro-5-(1-piperidinylmethyl)-3-(3-pyridinyl)-, (-)-, sulfate (1:1)
InChi Key
KRDJXQILWJDTAQ-UHFFFAOYSA-N
InChi Code
1S/C14H20N4O.H2O4S/c1-2-7-18(8-3-1)10-13-11-19-17-14(16-13)12-5-4-6-15-9-12;1-5(2,3)4/h4-6,9,13H,1-3,7-8,10-11H2,(H,16,17);(H2,1,2,3,4)
SMILES Code
OS(=O)(=O)O.C(C1CONC(=N1)c2cccnc2)N3CCCCC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 358.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Denes L, Bori Z, Csonka E, Entz L, Nagy Z. Reverse regulation of endothelial cells and myointimal hyperplasia on cell proliferation by a heatshock protein-coinducer after hypoxia. Stroke. 2008 Mar;39(3):1022-4. doi: 10.1161/STROKEAHA.107.495754. PubMed PMID: 18239173. 2: Kabakov AE, Budagova KR, Malyutina YV, Latchman DS, Csermely P. Pharmacological attenuation of apoptosis in reoxygenated endothelial cells. Cell Mol Life Sci. 2004 Dec;61(24):3076-86. PubMed PMID: 15583868. 3: Denes L, Entz L, Jancsik V. Restenosis and therapy. Int J Vasc Med. 2012;2012:406236. doi: 10.1155/2012/406236. PubMed PMID: 22489270; PubMed Central PMCID: PMC3303576. 4: Dénes L, Jednákovits A, Hargitai J, Pénzes Z, Balla A, Tálosi L, Krajcsi P, Csermely P. Pharmacologically activated migration of aortic endothelial cells is mediated through p38 SAPK. Br J Pharmacol. 2002 Jun;136(4):597-603. PubMed PMID: 12055138; PubMed Central PMCID: PMC1573374.