MedKoo Cat#: 576763 | Name: Irindalone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Irindalone is an S2-serotonergic antagonist.

Chemical Structure

Irindalone
Irindalone
CAS#96478-43-2

Theoretical Analysis

MedKoo Cat#: 576763

Name: Irindalone

CAS#: 96478-43-2

Chemical Formula: C24H29FN4O

Exact Mass: 408.2325

Molecular Weight: 408.52

Elemental Analysis: C, 70.56; H, 7.16; F, 4.65; N, 13.71; O, 3.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Irindalone
IUPAC/Chemical Name
(+)-(1R,3S)-1-(2-(4-(3-(p-Fluorophenyl)-1-indanyl)-1-piperazinyl)ethyl)-2-imidazolidinone
InChi Key
GHAMYXPEZSUOCU-XZOQPEGZSA-N
InChi Code
InChI=1S/C24H29FN4O/c25-19-7-5-18(6-8-19)22-17-23(21-4-2-1-3-20(21)22)28-14-11-27(12-15-28)13-16-29-10-9-26-24(29)30/h1-8,22-23H,9-17H2,(H,26,30)/t22-,23+/m0/s1
SMILES Code
Fc1ccc(cc1)[C@@H]2C[C@@H](N3CCN(CCN4CCNC4=O)CC3)c5ccccc25
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 408.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Gradin K, Carlsson S, Hedner T, Persson B. Cardiovascular effects of irindalone, a new S2-serotonergic antagonist, in the rat. Pharmacol Toxicol. 1990 Sep;67(3):199-204. doi: 10.1111/j.1600-0773.1990.tb00813.x. PMID: 2255675. 2. Gradin K, Hedner T, Persson B. Antihypertensive effects of chronic 5-hydroxytryptamine (5-HT2) receptor blockade with irindalone in the spontaneously hypertensive rat. J Neural Transm Gen Sect. 1991;83(3):227-33. doi: 10.1007/BF01253392. PMID: 1674420. 3. Mikkelsen EO, Nyborg NC, Jensen KT, Boeck V. Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8. doi: 10.1016/0014-2999(88)90053-2. PMID: 3396624.