CAY10784 is a STAT3 inhibitor (IC50 = 0.74 µM in a reporter assay) and a derivative of WP1066. It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 µM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 µM for both). CAY10784 is also active against H. pylori and C. jejuni (MICs = 1.6 and 4.7 µM, respectively).
MedKoo Cat#: 464671
Name: CAY10784
CAS#: 1245814-52-1
Chemical Formula: C11H6F3N3O3S
Exact Mass: 317.0082
Molecular Weight: 317.24
Elemental Analysis: C, 41.65; H, 1.91; F, 17.97; N, 13.25; O, 15.13; S, 10.11
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 94.58 | |
| DMF:PBS (pH 7.2) (1:2) | 0.3 | 1.04 | |
| DMSO | 10.0 | 31.53 | |
| Ethanol | 1.0 | 3.15 |
The following data is based on the product molecular weight 317.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
