Irazepine | CAS# 71735-92-7 | Biochemical

MedKoo Cat#: 576754 | Name: Irazepine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Irazepine an alkylating benzodiazepine.

Chemical Structure

Irazepine

CAS#71735-92-7

Theoretical Analysis

MedKoo Cat#: 576754

Name: Irazepine

CAS#: 71735-92-7

Chemical Formula: C18H13ClFN3OS

Exact Mass: 373.0452

Molecular Weight: 373.83

Elemental Analysis: C, 57.83; H, 3.51; Cl, 9.48; F, 5.08; N, 11.24; O, 4.28; S, 8.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Irazepine

IUPAC/Chemical Name

2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2-isothiocyanatoethyl)-

InChi Key

LTKSVYFAUMFQML-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H13ClFN3OS/c19-12-5-6-16-14(9-12)18(13-3-1-2-4-15(13)20)22-10-17(24)23(16)8-7-21-11-25/h1-6,9H,7-8,10H2

SMILES Code

Fc1ccccc1C2=NCC(=O)N(CCN=C=S)c3ccc(Cl)cc23

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 373.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Skolnick P, Schweri M, Kutter E, Williams E, Paul S. Inhibition of [3H]diazepam and [3H]3-carboethoxy-beta-carboline binding by irazepine: evidence for multiple "domains" of the benzodiazepine receptor. J Neurochem. 1982 Oct;39(4):1142-6. doi: 10.1111/j.1471-4159.1982.tb11507.x. PMID: 6288861. 2. Rice KC, Brossi A, Tallman J, Paul SM, Skolnick P. Irazepine, and noncompetitive, irreversible inhibitor of 3H-diazepam binding to benzodiazepine receptors. Nature. 1979 Apr 26;278(5707):854-5. doi: 10.1038/278854a0. PMID: 440412. 3. Williams EF, Rice KC, Mattson M, Paul SM, Skolnick P. In vivo effects of two novel alkylating benzodiazepines, irazepine and kenazepine. Pharmacol Biochem Behav. 1981 Apr;14(4):487-91. doi: 10.1016/0091-3057(81)90307-5. PMID: 7232472.