MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 464652 | Name: D-528

Description:

WARNING: This product is for research use only, not for human or veterinary use.

D-528 is a novel potent triple reuptake inhibitor (DAT: Ki=7.94 nM; NET: Ki=14.6 nM; SERT: Ki=367 nM).

Chemical Structure

D-528
D-528
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464652

Name: D-528

CAS#: unknown

Chemical Formula: C26H27F2NO4

Exact Mass: 455.1908

Molecular Weight: 455.50

Elemental Analysis: C, 68.56; H, 5.97; F, 8.34; N, 3.08; O, 14.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
D-528; D 528; D528;
IUPAC/Chemical Name
(2S,4R,5R)-2-(bis(4-fluorophenyl)methyl)-5-((3-hydroxy-4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol
InChi Key
YRHDAVRJWWPJIW-RQTOMXEWSA-N
InChi Code
InChI=1S/C26H27F2NO4/c1-32-24-11-2-16(12-23(24)31)14-29-21-15-33-25(13-22(21)30)26(17-3-7-19(27)8-4-17)18-5-9-20(28)10-6-18/h2-12,21-22,25-26,29-31H,13-15H2,1H3/t21-,22-,25+/m1/s1
SMILES Code
O[C@@H]1C[C@@H](C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)OC[C@H]1NCC4=CC=C(OC)C(O)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 455.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Santra S, Kortagere S, Vedachalam S, Gogoi S, Antonio T, Reith MEA, Dutta AK. Novel Potent Dopamine-Norepinephrine and Triple Reuptake Uptake Inhibitors Based on Asymmetric Pyran Template and Their Molecular Interactions with Monoamine Transporters. ACS Chem Neurosci. 2021 Apr 21;12(8):1406-1418. doi: 10.1021/acschemneuro.1c00078. Epub 2021 Apr 12. PMID: 33844493.